ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026
Catechol Derivative-Based Bioadhesives: Molecular Design for Precision Medical Adhesion.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Multifunctional Hydrogel-Based Scaffolds: Integrating Conductive Nanomaterials for Smart Wound Healing Applications.Gels (Basel, Switzerland) · 2026Review
- Efficacy and Safety of a Bioinspired Chitosan-Catechol/Gelatin Hemostatic Patch vs. TachoSil in Hepatectomy: A Randomized Noninferiority Trial.Biomedicines · 2026Article
- A robust adhesive microneedle for oral infections therapy via synergistic antibacterial and neutrophil-macrophage axis immunomodulation.Science advances · 2026Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Acute tissue injuries demand bioadhesives with strong wet adhesion, biocompatibility, and mechanical adaptability. While mussel-inspired catechol-based adhesives hold promise, current designs often neglect the role of molecular diversity in tuning cohesion-adhesion dynamics. Inspired by the hierarchical branching of trees, where branch length and position determine fruit composition, we developed a structurally tunable bioadhesive platform by grafting five DOPA-derived catechol derivatives-varying in side-chain length and substituents-onto polyvinyl alcohol (PVA) via esterification. Computational, spectroscopic, structural, and mechanical analyses revealed that side-chain length and substituents critically modulate the adhesive and cohesive properties of the hydrogels. Among these, the PVA-CA system exhibited superior cohesion and adhesion across diverse substrates, attributed to the extended side chain and conjugated double bond of caffeic acid (CA) that enhance intramolecular packing and interfacial interactions. Ex vivo adhesion on porcine/canine cardiac, pulmonary, and intestinal tissues, along with in vivo studies in hepatic defect and skin wound models, confirmed strong adhesion, biocompatibility, and improved tissue regeneration of PVA-CA hydrogel. This work establishes a programmable molecular design strategy for next-generation wet-tissue adhesives with broad biomedical potential.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.