Evidence map›Paper›PMID 41498537›Full record

ArticleHead & neck2026

Intraoperative Molecular Imaging Can Detect Large Nerve Perineural Invasion: A Case Report.

Carleigh R Burns, Aviva S Mattingly, Kim Ely, Andreja Radevic, Nicole Meeks, Sydea Maria Ahmad Zaidi, Brandee Brown, Georgii Vasiukov, Michael Topf, Eben Rosenthal

Registry-linked trialAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Head & neck, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05945875 (Official Title Targeted Dual Modality Imaging), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05945875 phase1recruitingnot on this map

Official Title Targeted Dual Modality Imaging (TDMI) for Detection and Removal of Head and Neck Cancer

TypeinterventionalSponsorVanderbilt-Ingram Cancer CenterRan2023 to 2028Enrolled40ConditionsHead and Neck Squamous Cell Carcinoma, Recurrent Head and Neck Squamous Cell CarcinomaArmsPanitumumab-IRDye800, Indium In 111 Panitumumab, Single Photon Emission Computed Tomography, Computed Tomography, Resection
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Carleigh R BurnsDepartment of Otolaryngology - Head and Neck Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID 0009-0006-3052-419X
Aviva S MattinglyDepartment of Otolaryngology - Head and Neck Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Kim ElyDepartment of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Andreja RadevicDepartment of Otolaryngology - Head and Neck Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Nicole MeeksDepartment of Otolaryngology - Head and Neck Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID 0009-0007-4021-8636
Sydea Maria Ahmad ZaidiDepartment of Otolaryngology - Head and Neck Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Brandee BrownDepartment of Otolaryngology - Head and Neck Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Georgii VasiukovDepartment of Otolaryngology - Head and Neck Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Michael TopfDepartment of Otolaryngology - Head and Neck Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID 0000-0002-1022-4417
Eben RosenthalDepartment of Otolaryngology - Head and Neck Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

Funding

Targeted Dual Modality Imaging for Detection and Removal of Head and Neck CancerR01CA266233 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI EBEN L. ROSENTHAL · 2022 to 2026
$2.1M
Augmented Reality to Guide Head and Neck Cancer SurgeryK08CA293255 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Michael Topf · 2024 to 2026
$645k
NCI NIH HHS 5K08CA293255-02NCI NIH HHS K08 CA293255NCI NIH HHS R01 CA266233
6 · The paper itself

Abstract

backgroundPerineural invasion (PNI) in head and neck squamous cell carcinoma (SCC) results in worse overall survival. Diagnosis requires resection and microscopic evaluation.

methodsA 63-year-old male with persistent cT4aN0 p16-positive SCC of the left base of tongue following chemoradiotherapy underwent salvage total glossectomy. Fluorescence-guided imaging of the wound bed was performed with PDE-GEN3 near-infrared (NIR) imaging following infusion of an optically EGFR-targeted antibody, Panitumumab-IRDye800 (pan800).

resultsThe proximal resected hypoglossal nerve was imaged intraoperatively and demonstrated a strong green fluorescence signal, raising concern for subclinical PNI. Biopsy of the nerve revealed SCC on frozen section analysis. This was re-resected with subsequent proximal margin negative for carcinoma. Postoperatively, ex vivo imaging of the nerve using PDE-GEN3 NIR imaging again demonstrated the presence of pan800 within the initial positive nerve margin, confirming subclinical PNI.

conclusionsThis case shows the feasibility of intraoperative fluorescence as a method to help identify subclinical PNI.

trial registrationClinicalTrials.gov identifier: NCT05945875.

Indexed as

Carcinoma, Squamous CellMolecular ImagingTongue NeoplasmsHumansMaleMiddle AgedNeoplasm InvasivenessPanitumumabPanitumumabfluorescence‐guided surgeryhead and neck squamous cell carcinomaintraoperative visualizationPanitumumab‐IRDye800perineural invasion

Identifiers

PMID41498537
PMCPMC13155179

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.