Evidence map›Paper›PMID 41498327›Full record

ArticleeLife2026

Replication stress-inducing ELF3 upregulation promotes BRCA1-deficient breast tumorigenesis in luminal progenitors.

Jiadong Zhou, Xiao Albert Zhou, Li Hu, Yujie Ma, Jun Zhan, Zhanzhan Xu, Mei Zhou, Qinjian Shen, Zhaofei Liu, Shaohua Ma and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jiadong Zhou *Department of Radiation Medicine, School of Basic Medical Sciences, Peking University International Cancer Institute, Institute of Advanced Clinical Medicine, State Key Laboratory of Molecular Oncology, Peking University Health Science Center, Beijing, China.
Xiao Albert Zhou *Department of Radiation Medicine, School of Basic Medical Sciences, Peking University International Cancer Institute, Institute of Advanced Clinical Medicine, State Key Laboratory of Molecular Oncology, Peking University Health Science Center, Beijing, China.ORCID 0000-0002-3726-4523
Li Hu *Familial and Hereditary Cancer Center, Peking University Cancer Hospital and Institute, Beijing, China.
Yujie MaDepartment of Radiation Medicine, School of Basic Medical Sciences, Peking University International Cancer Institute, Institute of Advanced Clinical Medicine, State Key Laboratory of Molecular Oncology, Peking University Health Science Center, Beijing, China.
Jun ZhanDepartment of Anatomy, Histology and Embryology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China.
Zhanzhan XuDepartment of Radiation Medicine, School of Basic Medical Sciences, Peking University International Cancer Institute, Institute of Advanced Clinical Medicine, State Key Laboratory of Molecular Oncology, Peking University Health Science Center, Beijing, China.
Mei ZhouDepartment of Radiation Medicine, School of Basic Medical Sciences, Peking University International Cancer Institute, Institute of Advanced Clinical Medicine, State Key Laboratory of Molecular Oncology, Peking University Health Science Center, Beijing, China.
Qinjian ShenDepartment of Radiation Medicine, School of Basic Medical Sciences, Peking University International Cancer Institute, Institute of Advanced Clinical Medicine, State Key Laboratory of Molecular Oncology, Peking University Health Science Center, Beijing, China.
Zhaofei LiuMedical Isotopes Research Center, Department of Radiation Medicine, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China.
Shaohua MaState Key Laboratory of Molecular Oncology, Beijing, Key Laboratory of Carcinogenesis and Translational Research, Department of Thoracic Surgery I, Peking University Cancer Hospital and Institute, Beijing, China.
Yuntao XieFamilial and Hereditary Cancer Center, Peking University Cancer Hospital and Institute, Beijing, China.
Jiadong WangDepartment of Radiation Medicine, School of Basic Medical Sciences, Peking University International Cancer Institute, Institute of Advanced Clinical Medicine, State Key Laboratory of Molecular Oncology, Peking University Health Science Center, Beijing, China.ORCID 0000-0002-9431-2413

Funding

National Key Research and Development Program of China 2022YFA1302800National Natural Science Foundation of China 82102997National Natural Science Foundation of China 82230089National Science Fund for Distinguished Young Scholars 82125031Postdoctoral Research Foundation of China 2024M750126Postdoctoral Research Foundation of China GZB20240037
6 · The paper itself

Abstract

BRCA1 is a critical tumor suppressor, mutations in which greatly increase risks for many tumors in carriers, most notably breast cancer. Luminal progenitor cells (LPs) are the currently recognized cells of origin of BRCA1-deficient breast cancers. However, the reason why LPs are prone to transform with BRCA1 deficiency has not been elucidated. Here, using single-cell sequencing of human

Indexed as

BRCA1 ProteinBreast NeoplasmsCarcinogenesisDNA-Binding ProteinsDNA ReplicationProto-Oncogene Proteins c-etsStem CellsTranscription FactorsUp-RegulationAnimalsFemaleHumansMiceBRCA1 ProteinBRCA1 protein, humanDNA-Binding ProteinsELF3 protein, humanProto-Oncogene Proteins c-etsTranscription FactorsBRCA1breast cancercancer biologyELF3geneticsgenomicshumanluminal progenitorsmouseReplication stress

Identifiers

PMID41498327
PMCPMC12779267

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.