ArticleIndian journal of ophthalmology2026
Spectral-domain optical coherence tomography characteristics in patients with transfusion-dependent thalassemia.
Article in Indian journal of ophthalmology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposePatients with transfusion-dependent thalassemia (TDT) are at risk of neuroretinal changes due to chronic anemia, hypoxia, iron overload, and chelation therapy. This study aims to compare central macular thickness (CMT), macular ganglion cell layer thickness (GCL), and peripapillary retinal nerve fiber layer (RNFL) measured using spectral-domain optical coherence tomography (SD-OCT) in TDT patients with controls.
methodsThis is a cross-sectional study of 170 eyes of 85 TDT patients between 5 and 30 years and 170 eyes of 85 controls with similar age ranges and sex distribution. Demographic characteristics, systemic characteristics, and SD-OCT-measured CMT, GCL thickness, and global and quadrant-wise peripapillary RNFL thickness were recorded.
resultsThere were 52 (61.2%) male and 33 (38.8%) female cases and 36 (42.4%) male and 49 (57.6%) female controls. The median age of TDT patients was 18 years (range: 6-30 years), while that of the controls was 21 years (range: 7-28 years). The mean GCL ( P = 0.002) and global ( P = 0.008), inferior ( P = 0.013), temporal ( P = 0.016), and nasal ( P = 0.023) RNFLs were thicker in controls than in TDT patients. There was no difference in CMT ( P = 0.495) and superior RNFL ( P = 0.303) between TDT patients and controls.
conclusionWhile no significant differences were observed in CMT or superior RNFL between the two groups, controls demonstrated greater GCL and RNFL thickness in three quadrants compared to TDT patients. These findings suggest the possibility of subtle neuroretinal alterations in TDT that may not yet be clinically evident. Larger longitudinal studies are recommended to validate these findings.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.