Evidence map›Paper›PMID 41498265›Full record

Trial reportInternational journal of dermatology2026

Molecular Changes Induced by Carbon Dioxide Laser in Hailey-Hailey Disease: A Potential Mechanism Underlying Treatment Efficacy.

Javier Antoñanzas, Agustín España, Ana Gorostidi, Ana Patiño-García, Marcos J Araúzo-Bravo, Daniela Gerovska, Rafael Salido-Vallejo, Leyre Aguado-Gil

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in International journal of dermatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Javier AntoñanzasDermatology Department, Clínica Universidad de Navarra, Pamplona, Navarra, Spain.
Agustín EspañaDermatology Department, Clínica Universidad de Navarra, Pamplona, Navarra, Spain.
Ana GorostidiGenomics Platform, Biogipuzkoa Health Research Institute, Donostia-San Sebastián, Spain.
Ana Patiño-GarcíaMedical Genomics Unit, University Clinic of Navarra, School of Medicine, University of Navarra, Pamplona, Spain.ORCID https://orcid.org/0000-0002-4066-8203
Marcos J Araúzo-BravoComputational Biology and Systems Biomedicine, Biogipuzkoa Health Research Institute, Donostia-San Sebastián, Spain.ORCID https://orcid.org/0000-0002-3264-464X
Daniela GerovskaComputational Biology and Systems Biomedicine, Biogipuzkoa Health Research Institute, Donostia-San Sebastián, Spain.
Rafael Salido-VallejoDermatology Department, Clínica Universidad de Navarra, Pamplona, Navarra, Spain.
Leyre Aguado-GilDermatology Department, Clínica Universidad de Navarra, Pamplona, Navarra, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionHailey-Hailey disease (HHD) is a rare genodermatosis caused by mutations in the ATP2C1 gene that codes for SPCA1, a calcium transporter in the epidermis. HHD impairs quality of life, and no curative treatment exists.

methodsTo confirm the efficacy and safety of CO

resultsLaser treatment provided a significant reduction in the lesioned area (p < 0.002). Gene expression analysis revealed reduced ATP2C1 expression in lesional skin and high expression of genes related to keratinocyte proliferation and IL-17-dependent inflammation. Interestingly, in affected skin after laser treatment, there was an enhancement of ATP2C1 with a reduced expression of genes related to keratinocyte proliferation and IL-17-dependent inflammation.

conclusionsCO

Indexed as

Calcium-Transporting ATPasesLasers, GasPemphigus, Benign FamilialAdultCell ProliferationFemaleGene ExpressionHumansKeratinocytesMaleMiddle AgedProspective StudiesSkinTreatment OutcomeATP2C1 protein, humanCalcium-Transporting ATPasescarbon dioxide lasergene expressionHailey‐Haileymolecular changes

Identifiers

PMID41498265
PMCPMC12979241

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.