ArticleJournal of the American Chemical Society2026
Click-Enabled Grafting for Adaptive Chiral Recognition in Porous Crystals.
Article in Journal of the American Chemical Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
6 authors.
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Abstract
Reticular frameworks are promising candidates for chiral environments, yet most rely on static stereogenic units, overlooking adaptive host-guest interactions in enantioselective recognition. We report a modular postsynthetic click strategy to install amino acid-derived peptidic moieties into UiO-68 frameworks without compromising crystallinity. Only the histidine-functionalized material exhibits high enantioselectivity for cetirizine. Simulations reveal adaptive interaction pockets, emphasizing the importance of local pore reorganization in chiral molecular recognition.
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Registered trials
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