Evidence map›Paper›PMID 41498247›Full record

ArticleEmerging microbes & infections2026

Low-replication influenza virus mediates high pathogenicity through an inflammation-driven lung-heart-brain axis in mice.

Wenfei Zhu, Zhuoya Xu, Xinglian Wang, Xiyan Li, Zi Li, Guolin Dong, Lei Yang, Ye Zhang, Ruina You, Yousong Peng and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Emerging microbes & infections, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Wenfei ZhuNHC Key Laboratory of Medical Virology and Viral Diseases, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (CDC), National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Disease, Beijing, People's Republic of China.
Zhuoya XuBioinformatics Center, College of Biology, Hunan Provincial Key Laboratory of Medical Virology, Hunan Research Center of the Basic Discipline for Cell Signaling, Hunan University, Changsha, People's Republic of China.
Xinglian WangBioinformatics Center, College of Biology, Hunan Provincial Key Laboratory of Medical Virology, Hunan Research Center of the Basic Discipline for Cell Signaling, Hunan University, Changsha, People's Republic of China.
Xiyan LiNHC Key Laboratory of Medical Virology and Viral Diseases, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (CDC), National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Disease, Beijing, People's Republic of China.
Zi LiNHC Key Laboratory of Medical Virology and Viral Diseases, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (CDC), National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Disease, Beijing, People's Republic of China.
Guolin DongBioinformatics Center, College of Biology, Hunan Provincial Key Laboratory of Medical Virology, Hunan Research Center of the Basic Discipline for Cell Signaling, Hunan University, Changsha, People's Republic of China.
Lei YangNHC Key Laboratory of Medical Virology and Viral Diseases, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (CDC), National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Disease, Beijing, People's Republic of China.
Ye ZhangNHC Key Laboratory of Medical Virology and Viral Diseases, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (CDC), National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Disease, Beijing, People's Republic of China.
Ruina YouBioinformatics Center, College of Biology, Hunan Provincial Key Laboratory of Medical Virology, Hunan Research Center of the Basic Discipline for Cell Signaling, Hunan University, Changsha, People's Republic of China.
Yousong PengBioinformatics Center, College of Biology, Hunan Provincial Key Laboratory of Medical Virology, Hunan Research Center of the Basic Discipline for Cell Signaling, Hunan University, Changsha, People's Republic of China.
Dayan WangNHC Key Laboratory of Medical Virology and Viral Diseases, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (CDC), National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Disease, Beijing, People's Republic of China.ORCID 0000-0002-4990-1016

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The outcomes of viral infections typically correlate with viral load in host tissues. In this study, we identified a H3N2 strain A/Environment/Guangxi/44461/2019 (GX19) that induced rapid mortality in mice by 4 days post-infection despite exhibiting low pulmonary replication capacity. Pathological analysis revealed that GX19 at 10

Indexed as

BrainHeartInflammationInfluenza A Virus, H3N2 SubtypeLungOrthomyxoviridae InfectionsAnimalsFemaleHumansMaleMiceMyocardiumViral LoadVirulenceVirus Replication

Identifiers

PMID41498247
PMCPMC12781936

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.