Trial reportAesthetic surgery journal2026
Improved Infraorbital Hollowing in Chinese Adults Following Hyaluronic Acid-based Filler With Lidocaine (VYC-15L) Treatment.
Trial report in Aesthetic surgery journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Evaluation of the Efficacy and Safety of Injectable Cross-Linked Sodium Hyaluronate Gel Containing Lidocaine for Correcting Infraorbital Hollowing.Aesthetic plastic surgery · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
backgroundInfraorbital hollowing (IOH) is characterized by a sunken appearance of the lower eyelid. The soft tissue filler VYC-15L has been demonstrated to be effective in correcting IOH in US and European populations.
objectivesThe aim was to assess the safety and effectiveness of VYC-15L treatment in Chinese adults with moderate to severe IOH.
methodsIn this randomized, multicenter, 12-month study, the primary endpoint was the proportion of ≥1-grade improvements on the Allergan Infraorbital Hollowing Scale (AIHS) according to the evaluating investigator (EI) at Month 3. Secondary endpoints included EI-based and participant-based assessments with the Global Aesthetic Improvement Scale (GAIS) and FACE-Q responses evaluated at Month 3. Safety was monitored throughout.
resultsThe primary endpoint was met with a 94.6% AIHS responder rate in the VYC-15L group vs 0.0% in the delayed-treatment control (DTC) group (P < .0001). Significant GAIS improvements in VYC-15L vs DTC participants were seen in EI-assessed (99.1% vs 0.0%) and participant-assessed (95.6% vs 5.7%) responder rates at Month 3 (P < .0001). The mean change in FACE-Q scores was greater in the VYC-15L group than the DTC group at Month 3 (P < .0001). Improvements from VYC-15L treatment were seen across all effectiveness measures through Month 12. Mean pain scores were 2.9. Most injection site reactions were mild and resolved within 14 days. Forty-six participants (28.8%) experienced treatment-emergent adverse events (TEAEs), including treatment-related TEAEs (1.7%), which were blepharospasm (0.8%) and injection site bruising (0.8%). No serious TEAEs were reported.
conclusionsVYC-15L was effective and well tolerated for IOH correction in Chinese adults over up to 1 year. LEVEL OF EVIDENCE: 1 (THERAPEUTIC):
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.