Evidence map›Paper›PMID 41498210›Full record

ArticleThe Journal of clinical endocrinology and metabolism2026

Radiological Surveillance for Pituitary Adenomas in Multiple Endocrine Neoplasia Type 1: A Longitudinal Cohort Study.

Yetunde B Omotosho, Nayan U Vikram, Elizabeth C Wright, Venkata Dola, Wafa Abbas, Rana Tora, Lynn Bliss, Craig Cochran, Carl F Pieper, Prashant Chittiboina and 4 more

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In one paragraph

Article in The Journal of clinical endocrinology and metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Yetunde B OmotoshoMetabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20814, USA.
Nayan U VikramMetabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20814, USA.
Elizabeth C WrightOffice of the Director, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20814, USA.
Venkata DolaNational Institutes of Health Clinical Center, National Institutes of Health, Bethesda, MD 20814, USA.
Wafa AbbasMetabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20814, USA.
Rana ToraMetabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20814, USA.
Lynn BlissMetabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20814, USA.
Craig CochranMetabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20814, USA.
Carl F PieperDepartment of Biostatistics and Bioinformatics, Duke University School of Medicine, Durham, NC 27710, USA.
Prashant ChittiboinaNeurosurgery Unit for Pituitary and Inheritable Diseases, Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20814, USA.ORCID 0000-0001-9349-4756
Lee S WeinsteinMetabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20814, USA.
William F SimondsMetabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20814, USA.ORCID 0000-0001-7806-706X
Nadia BiassouNational Institutes of Health Clinical Center, National Institutes of Health, Bethesda, MD 20814, USA.
Smita JhaMetabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20814, USA.ORCID 0000-0001-9201-3340

Funding

NIDDK NIH HHS
6 · The paper itself

Abstract

contextPatients with multiple endocrine neoplasia type 1 (MEN1) are genetically predisposed to developing tumors of the parathyroid, pancreas, and anterior pituitary. While widespread genetic testing has increased early diagnoses, the value of radiological surveillance for pituitary adenomas in these patients remains unclear.

objectiveTo investigate the impact of pituitary magnetic resonance imaging (MRI) findings on patient management in MEN1.

designRetrospective longitudinal cohort study.

settingNIH Clinical Center. PATIENTS: Genetically confirmed MEN1 evaluated between 1977 and September 2024. MEASURES: Cumulative proportion and rate of intervention for nonfunctional adenomas.

resultsThree hundred twenty patients with a mean follow-up duration of 14 ± 12 years were identified. One hundred eighty-two out of 320 patients (57%) had pituitary adenomas, of whom 95/182 (52%) had nonfunctional adenomas. All patients with adenoma had biochemical evaluation at the time of pituitary MRI. There were 21/95 (22%) patients with nonfunctional adenomas that needed an intervention throughout their follow-up. The rate of intervention per 100 patient-years for nonfunctional adenomas was 3.1% (confidence interval 2.0-4.7%). All patients with nonfunctional adenoma who required an intervention reported symptoms or had an abnormal pituitary function test. Tumor volume of 38/48 (79%) nonfunctional adenomas followed over a mean of 8.3 ± 6.1 years remained stable. Only 42/518 (8.1%) MRIs for nonfunctional adenomas were prompted by clinical or biochemical abnormalities. Individualized imaging could have avoided approximately 4 MRIs per patient with nonfunctional microadenoma over their follow-up.

conclusionIn an overwhelming majority of patients with MEN1, radiological surveillance for nonfunctional pituitary adenomas offers minimal added benefit beyond patient-reported symptoms and pituitary function testing.

Indexed as

AdenomaMultiple Endocrine Neoplasia Type 1Pituitary NeoplasmsAdolescentAdultAgedCohort StudiesFemaleFollow-Up StudiesHumansLongitudinal StudiesMagnetic Resonance ImagingMaleMiddle AgedRetrospective StudiesYoung Adultheritable pituitary tumorsmeninneuroendocrine tumorspituitary screeningprolactinomastumor volumetrics

Identifiers

PMID41498210
PMCPMC13183421

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.