Evidence map›Paper›PMID 41498146›Full record

ArticleCirculation research2026

Location-Dependent Differences in Cardiac and Skeletal Muscle Dysfunction Associated With Truncating Titin (

Celine F Santiago, Inken G Huttner, Ailbhe K O'Brien, Melissa A B Amerudin, Pauline M Bennett, Jasmina Cvetkovska, Renee Chand, Mark Holt, Gunjan Trivedi, Louis W Wang and 5 more

Abstract read
In one paragraph

Article in Circulation research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Celine F Santiago *Molecular Cardiology and Biophysics Division, Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia (C.F.S., I.G.H., J.C., R.C., G.T., L.W.W., D.F.).ORCID 0000-0002-1549-3667
Inken G Huttner *Molecular Cardiology and Biophysics Division, Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia (C.F.S., I.G.H., J.C., R.C., G.T., L.W.W., D.F.).
Ailbhe K O'Brien *Randall Centre for Cell and Molecular Biophysics, and British Heart Foundation Centre of Research Excellence, King's College London, United Kingdom (A.K.O, M.A.B.A., M.H., M.G., Y.H.).
Melissa A B AmerudinRandall Centre for Cell and Molecular Biophysics, and British Heart Foundation Centre of Research Excellence, King's College London, United Kingdom (A.K.O, M.A.B.A., M.H., M.G., Y.H.).ORCID 0009-0006-1168-2870
Pauline M BennettRandall Centre for Cell and Molecular Biophysics, King's College London, United Kingdom (P.M.B.).ORCID 0000-0001-5754-0081
Jasmina CvetkovskaMolecular Cardiology and Biophysics Division, Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia (C.F.S., I.G.H., J.C., R.C., G.T., L.W.W., D.F.).ORCID 0009-0004-4649-3397
Renee ChandMolecular Cardiology and Biophysics Division, Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia (C.F.S., I.G.H., J.C., R.C., G.T., L.W.W., D.F.).ORCID 0009-0007-9046-7649
Mark HoltRandall Centre for Cell and Molecular Biophysics, and British Heart Foundation Centre of Research Excellence, King's College London, United Kingdom (A.K.O, M.A.B.A., M.H., M.G., Y.H.).ORCID 0000-0001-7775-8539
Gunjan TrivediMolecular Cardiology and Biophysics Division, Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia (C.F.S., I.G.H., J.C., R.C., G.T., L.W.W., D.F.).ORCID 0000-0001-9541-4078
Louis W WangMolecular Cardiology and Biophysics Division, Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia (C.F.S., I.G.H., J.C., R.C., G.T., L.W.W., D.F.).ORCID 0000-0001-6907-150X
Xiaoping YangCEMS Proteomics Facility, King's College London, United Kingdom (X.Y.).ORCID 0009-0004-3542-4038
Kelly A SmithDepartment of Anatomy & Physiology, School of Biomedical Sciences, University of Melbourne, Victoria, Australia (K.A.S.).ORCID 0000-0002-8283-9760
Mathias GautelRandall Centre for Cell and Molecular Biophysics, and British Heart Foundation Centre of Research Excellence, King's College London, United Kingdom (A.K.O, M.A.B.A., M.H., M.G., Y.H.).ORCID 0000-0003-4027-9803
Diane FatkinMolecular Cardiology and Biophysics Division, Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia (C.F.S., I.G.H., J.C., R.C., G.T., L.W.W., D.F.).ORCID 0000-0002-9010-9856
Yaniv HinitsRandall Centre for Cell and Molecular Biophysics, and British Heart Foundation Centre of Research Excellence, King's College London, United Kingdom (A.K.O, M.A.B.A., M.H., M.G., Y.H.).ORCID 0000-0002-2682-1603

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTruncating variants in the

methodsWe generated 6 zebrafish lines carrying truncating

resultsHomozygous embryos from all lines except the C-terminal line, e232, showed a significant reduction of Z-disk and I-band

conclusionsOur data suggest that cardiac and skeletal muscle dysfunction associated with truncating

Indexed as

ConnectinMuscle, SkeletalMyocardiumZebrafish ProteinsAnimalsAnimals, Genetically ModifiedHomozygoteMutationPhenotypeSarcomeresZebrafishConnectinZebrafish Proteinscardiomyopathiesconnectin (titin)muscular diseasessarcomereszebrafish

Identifiers

PMID41498146
PMCPMC12854356

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.