Evidence map›Paper›PMID 41498106›Full record

ArticleJournal of toxicology2025

Impact of Diets Supplemented With Low Glycemic Index Starch on Physiology and Locomotor Abilities of Mice.

Khanh Son Trinh, Minh Hai Nguyen, Vinh Tien Nguyen

Abstract read
In one paragraph

Article in Journal of toxicology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Khanh Son TrinhFaculty of Chemical and Food Technology, Ho Chi Minh City University of Technology and Education, Ho Chi Minh City, 70000, Vietnam, hcmute.edu.vn.ORCID https://orcid.org/0000-0002-6365-2693
Minh Hai NguyenFaculty of Chemical and Food Technology, Ho Chi Minh City University of Technology and Education, Ho Chi Minh City, 70000, Vietnam, hcmute.edu.vn.ORCID https://orcid.org/0009-0005-8410-5110
Vinh Tien NguyenFaculty of Chemical and Food Technology, Ho Chi Minh City University of Technology and Education, Ho Chi Minh City, 70000, Vietnam, hcmute.edu.vn.ORCID https://orcid.org/0000-0002-1863-4138

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study explores the effects of a low glycemic index starch (HR0) produced through double thermal retrogradation (4°C/18 h-30°C/6 h), on the physiology and behavior of mice. HR0 starch exhibited low in vitro and in vivo glycemic indexes of 37 and 51, respectively. Mice fed a high-fat diet supplemented with 33% HR0 starch showed significant reductions in body weight compared to those on a high-fat diet. HR0 supplementation normalized fasting plasma glucose levels in mice, preventing the development of diabetes, while all other high-fat diet groups developed diabetic symptoms. Blood lipid analysis indicated that HR0 reduced triglycerides, LDL cholesterol, and total cholesterol levels while increasing HDL cholesterol. Histological examinations showed that HR0 improved the health of liver, kidney, and adipose tissues, notably reducing the incidence of fatty liver disease. Behavioral tests demonstrated that HR0 starch enhanced locomotor activity and reduced anxiety levels. These results suggest that HR0 starch can effectively improve metabolic health and may serve as a beneficial dietary supplement for individuals at risk of obesity, diabetes, and cardiovascular diseases.

Identifiers

PMID41498106
PMCPMC12767091

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.