ArticleCancer management and research2025
Analysis of Efficacy and Survival Prognosis for Astragalus Polysaccharide Injection as Adjuvant Therapy in Non - Small Cell Lung Cancer: A Propensity Score Matching - Based Study.
Article in Cancer management and research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Identification of a metastasis-associated prognostic gene signature in osteosarcoma through integrated bioinformatics and functional analysis.Mammalian genome : official journal of the International Mammalian Genome Society · 2026Article
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Authors and funding
8 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Background: Non-small cell lung cancer (NSCLC) is a prevalent malignancy where adjuvant therapy is crucial. Astragalus polysaccharide injection (APS-I) has shown potential as an adjunct due to its immunomodulatory properties, but its impact on survival outcomes requires further validation. Objective: This study employed propensity score matching (PSM) to evaluate the efficacy of APS-I combined with conventional therapy versus conventional therapy alone in the adjuvant treatment of NSCLC. Methods: In this retrospective cohort study, NSCLC patients receiving adjuvant therapy between January 2018 and December 2024 were enrolled. After 1:1 PSM, 54 matched pairs were allocated to the APS-I + conventional therapy group or the conventional therapy alone group. Outcomes included objective response rate (ORR), disease control rate (DCR), progression-free survival (PFS), overall survival (OS), immune function, quality of life (QoL), and adverse events. Results: The APS-I group demonstrated significantly superior short-term efficacy, with higher ORR (77.8% vs 33.3%, P<0.001) and DCR (96.3% vs 70.4%, P<0.001). Survival outcomes were significantly improved: median PFS was 12.8 months versus 8.2 months (Hazard Ratio [HR]= 0.143, 95% CI: 0.082-0.250, P<0.001), and median OS was 23.3 months versus 17.0 months (HR= 0.249, 95% CI: 0.154-0.401, P<0.001). The APS-I group also showed a significantly higher Karnofsky Performance Status (KPS) improvement rate (60.5% vs 27.9%, P=0.003) and a lower incidence of adverse events (11.1% vs 33.3%, P=0.014). Conclusion: APS-I combined with conventional therapy shows promise in improving survival and quality of life, but multicenter RCTs are warranted to validate efficacy before clinical adoption.
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