ArticleJournal of biomedical optics2026
Monte Carlo analysis of light fluence rate distribution in pleural photodynamic therapy: a study of geometric and optical property effects on treatment delivery.
Article in Journal of biomedical optics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- 3D Reactive Oxygen Species Dosimetry in Pleural Photodynamic Therapy: Integration of Macroscopic Kinetic Modeling and Deformable Registration.Antioxidants (Basel, Switzerland) · 2026Article
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Authors and funding
4 authors.
Funding
Abstract
Significance: Pleural photodynamic therapy (PDT) faces significant dosimetry challenges due to complex light distribution patterns within the pleural cavity, where integrating sphere effects dominate light propagation. Accurate prediction of light fluence rate distributions is essential for optimizing treatment protocols and improving therapeutic outcomes in this emerging clinical application. Aim: The aim is to quantitatively analyze light fluence rate distributions in pleural PDT using Monte Carlo (MC) simulations in various cavity geometries and tissue optical properties, providing essential data for treatment planning. Approach: Graphics processing unit-accelerated MC simulations ( Results: MC statistical uncertainties averaged 1.9% across all voxels. Spherical cavities ( Conclusions: We demonstrate that patient-specific factors including cavity geometry, tissue optical properties, and surgical access considerations significantly influence light distribution in pleural PDT. The quantitative relationships established between these parameters and fluence patterns provide essential data for developing personalized treatment planning protocols to optimize therapeutic light delivery.
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