Evidence map›Paper›PMID 41498015›Full record

ArticleOxidative medicine and cellular longevity2025

Coffee Wastes: A Sustainable Source of Natural Compounds Suppressing Colorectal Cancer Cell Viability.

Mariavittoria Verrillo, Paola Cuomo, Cristina Pagano, Fabrizio Martora, Riccardo Spaccini, Rosanna Capparelli, Salvatore Velotto

Abstract read
In one paragraph

Article in Oxidative medicine and cellular longevity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mariavittoria VerrilloDepartment of Agricultural Sciences, University of Naples "Federico II", Portici, Italy, unina.it.ORCID https://orcid.org/0000-0003-0083-7372
Paola CuomoDepartment of Agricultural Sciences, University of Naples "Federico II", Portici, Italy, unina.it.ORCID https://orcid.org/0000-0003-4504-1714
Cristina PaganoDepartment of Molecular Medicine and Medical Biotechnology, University of Naples "Federico II", Naples, Italy, unina.it.ORCID https://orcid.org/0000-0002-9181-6595
Fabrizio MartoraDermatology Unit, Department of Clinical Medicine and Surgery, University of Naples "Federico II", Naples, Italy, unina.it.ORCID https://orcid.org/0000-0003-2523-050X
Riccardo SpacciniDepartment of Agricultural Sciences, University of Naples "Federico II", Portici, Italy, unina.it.ORCID https://orcid.org/0000-0002-9828-1992
Rosanna CapparelliDepartment of Agricultural Sciences, University of Naples "Federico II", Portici, Italy, unina.it.ORCID https://orcid.org/0000-0001-8614-6251
Salvatore VelottoDepartment of Human Science and Quality of Life Promotion, San Raffaele University, Rome, Italy, unisr.it.ORCID https://orcid.org/0000-0002-6395-5635

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Colorectal cancer (CRC) is one of the leading causes of cancer-related deaths worldwide. Emerging evidence suggests a rising incidence of CRC in younger adults, emphasizing the urgent need for innovative therapeutic strategies. The increasing attention on circular economy approaches has heightened interest in discovering natural compounds derived from recycled agri-food waste. These compounds are particularly promising due to their large array of bioactive functional components. In this study, we investigated the efficacy of a green compost derived from coffee wastes, known as humic substance (HS), in reducing CRC cell viability. Chemical characterization of HS from composted coffee waste (HS-COF) using

Indexed as

CoffeeColorectal NeoplasmsHumic SubstancesAntioxidantsCell ProliferationCell SurvivalHT29 CellsHumansAntioxidantsCoffeeHumic Substancesagri-food wastescell apoptosiscolorectal cancerhumic substancesnatural antioxidant supplements

Identifiers

PMID41498015
PMCPMC12767483

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.