ArticleCureus2025
Localized Immune-Complex Small-Vessel Vasculitis Presenting as Unilateral Myositis After Hepatitis A.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Immune-complex small-vessel vasculitis (ICSVV) is a subtype of vasculitis characterized by inflammation and necrosis of small blood vessels caused by deposition of circulating immune complexes in vessel walls, followed by complement activation and recruitment of inflammatory cells. It typically targets postcapillary venules in the skin, but other small vessels in muscles, kidneys, gastrointestinal tract, and other organs can also be affected. Vasculitic myositis is usually bilateral and symmetric, with only a few reports of muscle-limited disease. Hepatitis A virus (HAV) is an uncommon trigger of vasculitis, in contrast to the well-recognized associations of hepatitis B with polyarteritis nodosa and hepatitis C with cryoglobulinemic vasculitis. We report a case of a woman in her early 30s who experienced intense discomfort in her left groin and thigh, accompanied by swelling and fever, two months after a confirmed acute HAV infection. Laboratory studies demonstrated severe systemic inflammation (WBC 30×10³/µL, C-reactive protein (CRP) 348 mg/L, erythrocyte sedimentation rate (ESR) >100 mm/h) with normal creatine kinase (CK). Axial fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) and coronal MRI revealed diffuse left-thigh inflammation without abscess. MRI-guided biopsy of the vastus lateralis demonstrated transmural inflammation and fibrinoid necrosis of intramuscular arteries with mixed CD4+/CD20+ infiltrates and C5b-9 deposition, consistent with ICSVV. The patient received oral prednisone 1 mg/kg daily (tapered over 10 weeks) and methotrexate 15 mg weekly; CRP decreased to 3.4 mg/L within four weeks. Remission was achieved by six months, with only mild residual numbness. This case represents the first report of biopsy-proven unilateral immune-complex vasculitic myositis temporally associated with HAV infection. It emphasizes the importance of considering vasculitic myositis in the differential diagnosis of focal limb swelling with systemic inflammation, even when CK levels are normal. It also highlights the role of MRI-guided biopsy in establishing the diagnosis. Early immunosuppressive therapy can improve outcomes in this rare but treatable condition.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.