ArticleCureus2025
A Rare Case of Brain Manifestation of Manganese Toxicity and Its Management: A Case Report and Literature Review.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Trace Elements Dyshomeostasis and Toxic Metals Neurotoxicity in Neurodegenerative Diseases.Biological trace element research · 2026Review
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Authors and funding
8 authors.
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Abstract
Manganese (Mn) toxicity is a rare but perplexing condition, often difficult to diagnose due to its unusual clinical presentation. Mn toxicity's neurological symptoms can be nonspecific, making early diagnosis crucial. The unique association between chronic liver disease and Mn toxicity highlights the need for increased clinical awareness and further research. We present a case of a five-year-old Asian male child with chronic liver disease who presented with neurological symptoms due to brain Mn deposition and its management. Notably, Mn exhibits a propensity for preferential accumulation in the basal ganglia, specifically targeting dopamine-producing (DAergic) neurons. The child's response to interventions, including a reduction in Mn deposition in the brain using chelating therapy, underscores the significance of early recognition and comprehensive management in addressing this condition. This case report delves into an exceptional instance of Mn toxicity, emphasizing the significance of early recognition and interdisciplinary intervention.
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