ArticleStem cells international2025
Ferulic Acid Alleviates Inflammation and Promotes Osteogenic Differentiation in Periodontitis by Inhibiting NF-
Article in Stem cells international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Ferulic Acid Modulates High Glucose-Induced MMP-1/TIMP-1 Imbalance and Enhances Wound Closure of Human Gingival Fibroblasts.Biomedicines · 2026Article
- Electro-controlled assembled of biphasic guided bone regeneration membrane for healing of diabetic periodontal bone defects.Journal of nanobiotechnology · 2026Article
- Ferulic Acid Alleviates Inflammation and Promotes Osteogenic Differentiation in Periodontitis by Inhibiting NF-Stem cells international · 2025Article
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Authors and funding
3 authors.
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Abstract
Background: Periodontitis refers to a chronic inflammatory illness that induces the destruction of periodontal tissues and can be driven by bacterial lipopolysaccharide (LPS) of pathogens. This study investigated the anti-inflammatory potential and underlying mechanisms of ferulic acid (FA) in periodontitis. Method: An in vitro periodontitis model was established by treating human periodontal ligament stem cells (hPDLSCs) with 10 µg/mL LPS for 24 h. The experimental groups included a control group, an LPS-treated group, and an LPS + FA cotreatment group. In addition, phorbol 12-myristate 13-acetate (PMA) treatment was used for nuclear factor Result: This study uncovered that FA alleviates LPS-induced inflammatory responses in hPDLSCs, promoting cell proliferation and osteogenic differentiation. FA inhibits NF- Conclusion: This study evaluated FA's effects on inflammation and osteogenic function in LPS-induced hPDLSCs, revealing its potential to alleviate periodontitis via NF-
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