ArticleJournal of ophthalmology2025
Safety Profile of Intraoperative Corneal Debridement in Descemet Membrane Endothelial Keratoplasty (DMEK)-A Retrospective Comparative Study.
Article in Journal of ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Safety Profile of Intraoperative Corneal Debridement in Descemet Membrane Endothelial Keratoplasty (DMEK)-A Retrospective Comparative Study.Journal of ophthalmology · 2025Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: To investigate the influence of intraoperative corneal debridement on postoperative outcomes in Descemet Membrane Endothelial Keratoplasty (DMEK). Methods: This retrospective comparative study analyzed 3168 eyes that underwent DMEK between 2012 and 2024. Intraoperative corneal debridement was performed in 215 eyes (6.8%) to improve visualization during the procedure. Survival time analyses with Kaplan-Meier curves and log-rank test and multifactorial Cox regression were conducted to assess the impact of corneal debridement on postoperative graft survival. Results: Bivariate survival analyses suggested that intraoperative corneal debridement during DMEK may be associated with worse postoperative outcomes in terms of visual acuity, endothelial cell density, graft survival, and perioperative complications. Using the log-rank test, significant differences were observed in endothelial cell density, postoperative regrafting, and visual acuity ( Conclusions: In bivariate analyses, intraoperative corneal debridement was associated with worse postoperative outcomes, including reduced visual acuity, endothelial cell density, and graft survival. However, these differences likely reflect the more severe cases in the debridement group. When adjusting for potential confounders, multifactorial Cox regression analysis showed that corneal debridement did not have a significant impact on graft survival. This suggests that while debridement may be associated with poorer outcomes in unadjusted analyses, it does not appear to adversely affect graft survival when accounting for other factors. Corneal debridement may therefore be a safe and viable option in DMEK, though further research is needed to confirm its impact on long-term outcomes.
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