ArticleJournal of ophthalmology2025
New Clues to the Pathogenesis of Idiopathic Orbital Inflammation: Elevated IL-8 and MCP-1 in Tear Fluid.
Article in Journal of ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- New Clues to the Pathogenesis of Idiopathic Orbital Inflammation: Elevated IL-8 and MCP-1 in Tear Fluid.Journal of ophthalmology · 2025Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objectives: To characterize tear cytokine profiles in patients with idiopathic orbital inflammation (IOI) and analyze the expression of altered cytokines in blood and involved tissues. Methods: This case-control study enrolled 18 IOI patients and 11 age-/sex-matched controls. Ocular Surface Disease Index (OSDI), corneal fluorescent staining, tear film breakup time (TBUT), Schirmer I test, and other clinical and laboratory parameters were obtained from all participants. Concentrations of cytokines in tear fluid, blood, and tissues were determined using a multiplex bead immunoassay system, enzyme-linked immunosorbent assay, and immunohistochemistry. Results: Significantly elevated levels of interleukin (IL)-8 and monocyte chemoattractant protein (MCP)-1 (both Conclusions: The dysregulation of tear cytokine profiles provides a new insight into the potential immunologic mechanism for IOI. The elevated IL-8 and MCP-1 may represent candidate biomarkers of IOI.
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