ArticleWorld journal of experimental medicine2025
Lack of cytoplasmic expression of a new marker programmed cell death ligand-1 in tumor cells is significant.
Article in World journal of experimental medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Changes in the metabolism of axillary lymph node cells as a predictor of regional metastasis in breast cancer.World journal of experimental medicine · 2026Article
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4 authors.
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Abstract
backgroundRecent studies have indicated that an antibody against programmed cell death protein 1-ligand 1 (PDCD1-LG1), a new marker of programmed cell death-ligand 1 expression, is promising for studying the mechanisms of breast cancer (BC) progression and resistance to chemotherapy.
aimTo compare the features of PDCD1-LG1 expression in chemoresistant luminal A BC and BC with high Ki67 indices.
methodsThis prospective single-center observational cohort study included 148 patients with newly diagnosed primary resectable BC. The tumor sections were stained with antibodies against PDCD1-LG1. The statistical calculations were performed using Statistica software version 12.0.
resultsCytoplasmic PDCD1-LG1 (cPDCD1-LG1) expression was detected in the nonneoplastic epithelium, tumor cells (TCs) and immune cells (ICs). A lack of cPDCD1-LG1 expression in ≥ 20% of TCs and a PDCD1-LG1+ IC score ≥ 10% were associated with aggressive BC characteristics, including tumor G3, estrogen receptor-negative status, overexpression of human epidermal growth factor receptor 2 (HER2+), luminal B HER2+ BC, nonluminal HER2+ BC and triple-negative BC. The lack of cPDCD1-LG1 expression in < 20% of the TCs, in combination with a PDCD1-LG1+ IC score < 10% and G1, was characteristic of chemoresistant luminal A BC, whereas the lack of cPDCD1-LG1 expression in ≥ 20% of the TCs, combined with a PDCD1-LG1+ IC score ≥ 10%, was a predictor of high BC sensitivity to chemotherapy.
conclusionThese results indicate that both the lack of cPDCD1 LG1 in TCs and the PDCD1 LG1 IC score and their combination may be important for assessing BC prognosis and sensitivity to chemotherapy.
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