Evidence map›Paper›PMID 41497688›Full record

ArticleWorld journal of experimental medicine2025

Immunohistochemical expression of epithelial mesenchymal transition proteins ZEB1 and E-cadherin in oral leukoplakia and oral squamous cell carcinoma.

Gouri S Panchannavar, Punnya V Angadi

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Article in World journal of experimental medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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0cells of the map it votes in
2citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

2 authors.

Gouri S PanchannavarDepartment of Oral and Maxillofacial Pathology, DAPM R V Dental College, Bengaluru, Bengaluru 560078, Karnataka, India.
Punnya V AngadiDepartment of Oral and Maxillofacial Pathology, KLE VK Institute of Dental Sciences, KLE Academy of Higher Education and Research, Belagavi 580010, Karnataka, India. punnya_angadi@rediffmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOral squamous cell carcinoma (OSCC) is a frequent cancer affecting the oral cavity. OSCC is usually preceded by occurrence of precursor lesions, which demonstrate a varying degree of malignant transformation potential. Epithelial-mesenchymal transition is a significant biological phenomenon that facilitates tumor growth and metastasis through the involvement of diverse epithelial and mesenchymal proteins. E-cadherin down regulation and over-expression of zinc-finger E-box-binding homeobox 1 (ZEB1) has been reported in several cancers.

aimTo evaluate the role of E-cadherin and ZEB1 in oral leukoplakia and OSCC.

methodsA total of 60 cases

resultsReduction in the expression E-cadherin and altered localization were noted from OED to OSCC. Overexpression of ZEB1 along with cytoplasmic accumulation was noted in OED, with marked expression in OSCC. ZEB1 epithelium intensity and ZEB1 connective tissue percentage contributed to the discriminant function with an accuracy of 85% for the classification of OED from OSCC.

conclusionLoss of E-cadherin and up-regulation of ZEB1 from OED to OSCC, predisposes to induction of epithelial-mesenchymal transition. Discriminant formulas are developed to classify cases of OED and OSCC with 85% accuracy.

Indexed as

E-cadherinEpithelial mesenchymal transitionOral epithelial dysplasiaOral leukoplakiaOral squamous cell carcinomaZinc-finger E-box-binding homeobox 1

Identifiers

PMID41497688
PMCPMC12767246

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