Evidence map›Paper›PMID 41497685›Full record

ArticleWorld journal of experimental medicine2025

Ganglion cell complex and retinal nerve fiber layer thickness in predicting visual outcome in brain tumors after surgery.

Sucheta Parija, Koyel Chakraborty, Rabi Narayan Sahu, Bhagabat Nayak, Ravikumar Subraya Rathod

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Article in World journal of experimental medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 citing paper in PubMed.

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5 · Who and what money

Authors and funding

5 authors.

Sucheta ParijaDepartment of Ophthalmology, All India Institute of Medical Sciences, Bhubaneshwar 751019, Odisha, India. ophthal_sucheta@aiimsbhubaneswar.edu.in.
Koyel ChakrabortyDepartment of Ophthalmology, All India Institute of Medical Sciences Kalyani, Kolkota 741245, West Bengal, India.
Rabi Narayan SahuDepartment of Neurosurgery, All India Institute of Medical Sciences Bhubaneswar, Bhubaneswar 751019, Odisha, India.
Bhagabat NayakDepartment of Ophthalmology, All India Institute of Medical Sciences, Bhubaneshwar 751019, Odisha, India.
Ravikumar Subraya RathodDepartment of Community Medicine, Government Medical College and Hospital, Chandigarh 160030, Chandīgarh, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAnterior visual pathway lesions can cause severe visual loss. Optical coherence tomography (OCT) can detect ganglion cell complex (GCC) thinning, even with normal retinal nerve fiber layer (RNFL) thickness and subtle visual field changes.

aimTo determine the proportion of eyes with RNFL and GCC thinning and their association with visual parameters in patients with brain tumors undergoing surgery.

methodsA prospective study was conducted on 37 patients (69 eyes) with peri-chiasmatic and chiasmatic brain tumors undergoing surgical decompression between February 2019 and June 2020 at a tertiary care institute. A comprehensive neuro-ophthalmological work-up, demographic and clinical profile documentation, and six-month postoperative follow-up weredone. Statistical analysis was significant at

resultsMean age was 35.14 ± 11.98 years. The best and worst visual outcomes were associated with the craniopharyngioma and meningioma groups, respectively (

conclusionIn chiasmal compression, RNFL and GCC thickness measurements using OCT can be a useful prognostic indicator for assessing visual recovery. An eye with structural damage, with significant RNFL and GCC loss, is a predictive factor of blindness. A minimum preoperative RNFL and GCC thickness of 73 µm and 58 µm, respectively, can preserve vision after surgery.

Indexed as

Brain tumorsChiasmatic compressionGanglion cell complexOptical coherence tomographyRetinal nerve fiber layerVisual fieldVisual prognosis

Identifiers

PMID41497685
PMCPMC12767244

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