ArticleWorld journal of experimental medicine2025
Evaluating palmitoyl-protein thioesterase 1 in oral squamous cell carcinoma: A novel indicator of tumor behavior and therapeutic response.
Article in World journal of experimental medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOral squamous cell carcinoma (OSCC) poses a major health burden, with frequent late-stage diagnoses and limited prognostic tools. Palmitoyl-protein thioesterase (PPT)1, a lysosomal enzyme, has been implicated in tumor biology. This study investigates PPT1 expression in OSCC and its association with clinicopathological features.
aimTo evaluate the immunohistochemical expression of PPT1 in OSCC and assess its correlation with patient age, gender, tumor grade, and TNM staging using H-score quantification.
methodsImmunohistochemistry for PPT1 was performed on 43 histopathologically confirmed OSCC samples. PPT1 expression was quantified using the H-score method (range: 0-300). Correlation with clinical parameters was assessed using Spearman's rank correlation and Kruskal-Wallis test.
resultsPPT1 expression showed a significant positive correlation with tumor grade (ρ = 0.48,
conclusionPPT1 expression is associated with histological tumor grade in OSCC and may reflect tumor aggressiveness. These initial results highlight the potential of PPT1 as a prognostic biomarker, warranting further validation in larger, multicenter studies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.