Evidence map›Paper›PMID 41497670›Full record

ArticlebioRxiv : the preprint server for biology2025

Corticolimbic structure-function coupling is sensitive to childhood adversity and buffers adversity-related symptoms during development.

Lucinda M Sisk, Taylor J Keding, Allison Drew, Emilie Ma, Golia Shafiei, Matthew Cieslak, Theodore D Satterthwaite, Dylan G Gee

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Lucinda M SiskDepartment of Psychology, Yale University, New Haven, CT.ORCID 0000-0003-4900-9770
Taylor J KedingDepartment of Psychology, Yale University, New Haven, CT.ORCID 0000-0002-0507-6712
Allison DrewDepartment of Psychology, Yale University, New Haven, CT.
Emilie MaDepartment of Psychology, Yale University, New Haven, CT.
Golia ShafieiPenn Lifespan Informatics and Neuroimaging Center (PennLINC), Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.ORCID 0000-0002-2036-5571
Matthew CieslakPenn Lifespan Informatics and Neuroimaging Center (PennLINC), Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.ORCID 0000-0002-1931-4734
Theodore D SatterthwaitePenn Lifespan Informatics and Neuroimaging Center (PennLINC), Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.ORCID 0000-0001-7072-9399
Dylan G GeeDepartment of Psychology, Yale University, New Haven, CT.ORCID 0000-0002-3685-2710

Funding

TRAINING PROGRAM IN CHILDHOOD NEUROPSYCHIATRIC DISORDERST32MH018268 · NIMH · YALE UNIVERSITY · PI Michael H Bloch, MICHAEL J CROWLEY · 1985 to 2026
$11.0M
Longitudinal Mapping of Network Development Underlying Executive Dysfunction in AdolescenceR01MH113550 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI Danielle Smith Bassett, Theodore Satterthwaite · 2018 to 2026
$6.9M
Inter-modal Coupling Image AnalyticsR01MH112847 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI Theodore Satterthwaite, Russell Takeshi Shinohara · 2017 to 2026
$5.9M
Precision mapping of individualized executive networks in youthR37MH125829 · NIMH · UNIVERSITY OF MINNESOTA · PI Damien A Fair, Theodore Satterthwaite · 2021 to 2026
$4.7M
The Neuroimaging Brain Chart Software SuiteU24NS130411 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI Christos Davatzikos, Yong Fan · 2023 to 2026
$3.7M
Reproducible imaging-based brain growth charts for psychiatryR01MH120482 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI MILHAM, MICHAEL PETER, SATTERTHWAITE, THEODORE · 2019 to 2023
$3.5M
Biomedical Image Computing and Informatics ClusterS10OD023495 · OD · UNIVERSITY OF PENNSYLVANIA · PI DAVATZIKOS, CHRISTOS · 2017 to 2017
$1.9M
Novel Mechanisms of Fear Reduction Targeting the Biological State of the Developing BrainDP5OD021370 · OD · YALE UNIVERSITY · PI GEE, DYLAN GRACE · 2015 to 2019
$1.3M
NIH HHS DP5 OD021370NIH HHS S10 OD023495NIMH NIH HHS R01 MH112847NIMH NIH HHS R01 MH113550NIMH NIH HHS R01 MH120482NIMH NIH HHS R37 MH125829NIMH NIH HHS T32 MH018268NINDS NIH HHS U24 NS130411
6 · The paper itself

Abstract

Childhood adversity is a potent predictor of mental health problems across the lifespan, and a rich cross-species literature implicates stress-sensitive corticolimbic circuits in adversity-related psychopathology. Structure-function coupling (SFC) is a promising multimodal marker that is sensitive to developmental plasticity. While emerging evidence suggests cortical SFC is sensitive to adversity exposure during early childhood, it is unknown how SFC in stress-sensitive corticolimbic circuits links adversity exposure with mental health across development. We examined associations between adversity exposure, transdiagnostic symptomatology, and both amygdala-cortical and hippocampal-cortical SFC across development in a large sample of youth (N = 607, 39% F). Results revealed that adversity exposure moderated age-related change in amygdala-vmPFC SFC (

Identifiers

PMID41497670
PMCPMC12767528

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.