Evidence map›Paper›PMID 41497664›Full record

ArticlebioRxiv : the preprint server for biology2025

MECP2 Duplication Uncouples Mitochondrial and Purine Metabolism During neuronal maturation.

Gerarda Cappuccio, Guantong Qi, Xuan Qin, Saleh Mahmud Khalil, John Hunyara, Yang Li, Joel Mathews, Armand Soriano, Sivan Osenberg, Senghong Sing and 17 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Gerarda CappuccioJan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, TX, 77030, USA.
Guantong QiJan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, TX, 77030, USA.
Xuan QinDepartment of Pathology & Immunology, Baylor College of Medicine, Houston, TX, 77030, USA.
Saleh Mahmud KhalilJan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, TX, 77030, USA.
John HunyaraIonis Pharmaceuticals, Carlsbad, California, CA 92010, USA.
Yang LiIonis Pharmaceuticals, Carlsbad, California, CA 92010, USA.
Joel MathewsIonis Pharmaceuticals, Carlsbad, California, CA 92010, USA.
Armand SorianoIonis Pharmaceuticals, Carlsbad, California, CA 92010, USA.
Sivan OsenbergJan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, TX, 77030, USA.
Senghong SingJan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, TX, 77030, USA.
Toni Claire TacordaJan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, TX, 77030, USA.
Luke ParkitnyJan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, TX, 77030, USA.
Jennifer SheppardJan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, TX, 77030, USA.
George TimponeJan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, TX, 77030, USA.
Sergio AttanasioDepartment of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Sara BitarJan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, TX, 77030, USA.
Ashley Grace AndersonJan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, TX, 77030, USA.
Demian Rocha IfaDepartment of Pathology & Immunology, Baylor College of Medicine, Houston, TX, 77030, USA.
Christine CoqueryIonis Pharmaceuticals, Carlsbad, California, CA 92010, USA.
Bernard SuterSection of Pediatric Neurology and Developmental Neuroscience, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.
Davut PehlivanJan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, TX, 77030, USA.
Hu ChenJan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, TX, 77030, USA.
Zhandong LiuJan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, TX, 77030, USA.
Feng LiDepartment of Pathology & Immunology, Baylor College of Medicine, Houston, TX, 77030, USA.
Huda Y ZoghbiJan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, TX, 77030, USA.
Paymaan Jafar-NejadIonis Pharmaceuticals, Carlsbad, California, CA 92010, USA.
Mirjana Maletic-SavaticJan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, TX, 77030, USA.

Funding

Preclinical and Clincial OutcomesP50HD103555 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI Sandesh Chakravarthy Sreenath Nagamani, David Loren Nelson · 2020 to 2026
$9.9M
Effects of 16p11.2 copy number variation on neuronal development and pathologyR01MH130356 · NIMH · BOSTON CHILDREN'S HOSPITAL · PI MIRJANA MALETIC-SAVATIC, MUSTAFA SAHIN · 2023 to 2026
$3.2M
Comprehensive Deep Phenotyping and Multi-omics to Develop Clinical and Molecular Biomarkers for MeCP2-related DiseasesK23NS125126 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI Davut Pehlivan · 2022 to 2026
$1.1M
NICHD NIH HHS P50 HD103555NIMH NIH HHS R01 MH130356NINDS NIH HHS K23 NS125126
6 · The paper itself

Abstract

Mitochondria and nucleotide metabolism are critical for cellular and developmental homeostasis, yet their potential interdependence and role in neurodevelopmental disease remain unclear. In

Indexed as

brain organoidsMeCP2metabolomemitochondriamultiomicsneuroprogenitorspurine

Identifiers

PMID41497664
PMCPMC12767650

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.