Evidence map›Paper›PMID 41497635›Full record

ArticlebioRxiv : the preprint server for biology2025

PACS1 syndrome variant alters proteomic landscape of developing cortical organoids.

Ximena Gomez-Maqueo, Lauren E Rylaarsdam, Ashley Woo, Annika L Schroder, Jennifer Rakotomamonjy, Clare L Bossert, Tess A Smith, Shelby Ruiz, Jordan Gilardi, Lambertus Klei and 3 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ximena Gomez-MaqueoDepartment of Neuroscience, Feinberg School of Medicine, Northwestern University, Chicago IL, USA.ORCID 0000-0001-9582-6558
Lauren E RylaarsdamDepartment of Neuroscience, Feinberg School of Medicine, Northwestern University, Chicago IL, USA.ORCID 0000-0002-1614-408X
Ashley WooDepartment of Neuroscience, Feinberg School of Medicine, Northwestern University, Chicago IL, USA.
Annika L SchroderDepartment of Neuroscience, Feinberg School of Medicine, Northwestern University, Chicago IL, USA.
Jennifer RakotomamonjyDepartment of Neuroscience, Feinberg School of Medicine, Northwestern University, Chicago IL, USA.
Clare L BossertDepartment of Neuroscience, Feinberg School of Medicine, Northwestern University, Chicago IL, USA.
Tess A SmithDepartment of Neuroscience, Feinberg School of Medicine, Northwestern University, Chicago IL, USA.
Shelby RuizDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.
Jordan GilardiDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.
Lambertus KleiDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.
Bernie DevlinDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.
Matthew L MacDonaldDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.
Alicia Guemez-GamboaDepartment of Neuroscience, Feinberg School of Medicine, Northwestern University, Chicago IL, USA.

Funding

Tumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Devalingam Mahalingam · 1993 to 2026
$153.9M
Fine-Mapping Genome-Wide Associated Loci using Multi-omics Data to Identify Mechanisms Affecting Serious Mental IllnessR01MH125235 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DEVLIN, BERNIE, MACDONALD, MATTHEW L · 2021 to 2024
$3.0M
Identifying pathogenic mechanisms underlying PACS1 Syndrome: implications for neural development - Research Supplement to PromoteDiversity in Health-Related Research #2R01NS123163 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ALICIA DIONE GUEMEZ GAMBOA · 2022 to 2026
$2.9M
Synaptic Protein Networks, Genetic Risk, and Spine Loss in SchizophreniaR01MH118497 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MACDONALD, MATTHEW L · 2019 to 2023
$2.5M
NCI NIH HHS P30 CA060553NIMH NIH HHS R01 MH118497NIMH NIH HHS R01 MH125235NINDS NIH HHS R01 NS123163
6 · The paper itself

Abstract

PACS1 syndrome is a neurodevelopmental disorder (NDD) resulting from a unique

Identifiers

PMID41497635
PMCPMC12767366

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.