Evidence map›Paper›PMID 41497593›Full record

ArticlebioRxiv : the preprint server for biology2025

A standardized and reproducible behavioral protocol to elicit visual spatial attention in mice.

Kayla Peelman, Nicole Allen, Jamin Ahn, Joseph Del Rosario, Kaitlin C Jacobson, Esther Kim, Anthony D Lien, Mercedes Lopez-Esteva, Lyndah Lovell, Kendell Worden and 3 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Kayla PeelmanDept of Biomedical Engineering, Georgia Institute of Technology & Emory University, Atlanta, GA, USA.
Nicole AllenDept of Biomedical Engineering, Georgia Institute of Technology & Emory University, Atlanta, GA, USA.
Jamin AhnDept of Biomedical Engineering, Georgia Institute of Technology & Emory University, Atlanta, GA, USA.
Joseph Del RosarioDept of Biomedical Engineering, Georgia Institute of Technology & Emory University, Atlanta, GA, USA.
Kaitlin C JacobsonDept of Biomedical Engineering, Georgia Institute of Technology & Emory University, Atlanta, GA, USA.
Esther KimDept of Biomedical Engineering, Georgia Institute of Technology & Emory University, Atlanta, GA, USA.
Anthony D LienDept of Biomedical Engineering, Georgia Institute of Technology & Emory University, Atlanta, GA, USA.
Mercedes Lopez-EstevaDept of Biomedical Engineering, Georgia Institute of Technology & Emory University, Atlanta, GA, USA.
Lyndah LovellDept of Biomedical Engineering, Georgia Institute of Technology & Emory University, Atlanta, GA, USA.
Kendell WordenDept of Biomedical Engineering, Georgia Institute of Technology & Emory University, Atlanta, GA, USA.
Yanlin YangDept of Biomedical Engineering, Georgia Institute of Technology & Emory University, Atlanta, GA, USA.
James ZhuangDept of Biomedical Engineering, Georgia Institute of Technology & Emory University, Atlanta, GA, USA.
Bilal HaiderDept of Biomedical Engineering, Georgia Institute of Technology & Emory University, Atlanta, GA, USA.ORCID 0000-0002-6382-1426

Funding

Training In Systems And Integrative Biology NeuroscienceT32NS096050 · NINDS · EMORY UNIVERSITY · PI Yoland Smith · 2016 to 2026
$3.9M
Circuit and Synaptic Mechanisms of Visual Spatial AttentionR01NS109978 · NINDS · GEORGIA INSTITUTE OF TECHNOLOGY · PI HAIDER, BILAL · 2018 to 2022
$2.3M
Tracking Flow of Attention in Visual Circuits Across the BrainRF1NS132288 · NINDS · GEORGIA INSTITUTE OF TECHNOLOGY · PI HAIDER, BILAL · 2023 to 2023
$1.4M
Functional organization and spatial resolution of attentional feedback from frontal to visual cortexR01EY036078 · NEI · GEORGIA INSTITUTE OF TECHNOLOGY · PI Bilal Haider · 2025 to 2026
$976k
The impact of behavioral state and spatial attention on sensory responses in the primary visual thalamusF31EY033691 · NEI · EMORY UNIVERSITY · PI PEELMAN, KAYLA · 2022 to 2024
$143k
NEI NIH HHS F31 EY033691NEI NIH HHS R01 EY036078NINDS NIH HHS R01 NS109978NINDS NIH HHS RF1 NS132288NINDS NIH HHS T32 NS096050
6 · The paper itself

Abstract

Understanding how neural activity gives rise to cognitive processes such as selective attention is a fundamental goal of neuroscience. An important but often overlooked advance towards this goal requires the development and sharing of rigorous and reproducible behavioral tasks across labs; this is particularly important given the recent surge in studies of cognition and perception in mice. Here, we developed a standardized training protocol for head-fixed mice to become experts in a psychometric visual contrast detection task in just 17 days. Experts detected stimuli at two distinct spatial locations for several hundred trials per day. As consecutive trials elapsed at either location, the speed, accuracy, and contrast sensitivity of visual perception improved - all hallmarks of spatial attention improving performance, as seen in primates. These findings validate the efficacy of this protocol to reveal multiple aspects of selective spatial attention in mice, establishing a rigorous and reproducible tool for the community.

Identifiers

PMID41497593
PMCPMC12767522

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.