Evidence map›Paper›PMID 41497584›Full record

ArticlebioRxiv : the preprint server for biology2025

Vitreous Inflammation as an Early Indicator of Retinal Ganglion Cell Loss Following Acute Optic Nerve Injury in Mice.

Shichu Chang, Weijia Fan, Jiahui Wu, Lei Xu, Virginia Lee, Charlotte Zhang, Edward P Kronenberg, Wenjin Xu, Hu Yang, Hao F Zhang and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Shichu ChangDepartment of Biology, University of Virginia, Charlottesville, VA.
Weijia FanDepartment of Biomedical Engineering, Northwestern University, Evanston, IL.
Jiahui WuDepartment of Biology, University of Virginia, Charlottesville, VA.
Lei XuLinda and Bipin Doshi Department of Chemical and Biochemical Engineering, Missouri University of Science and Technology, Rolla, MO.
Virginia LeeDepartment of Biology, University of Virginia, Charlottesville, VA.
Charlotte ZhangDepartment of Biology, University of Virginia, Charlottesville, VA.
Edward P KronenbergDepartment of Biology, University of Virginia, Charlottesville, VA.
Wenjin XuDepartment of Biology, University of Virginia, Charlottesville, VA.
Hu YangLinda and Bipin Doshi Department of Chemical and Biochemical Engineering, Missouri University of Science and Technology, Rolla, MO.
Hao F ZhangDepartment of Biomedical Engineering, Northwestern University, Evanston, IL.
Xiaorong LiuDepartment of Biology, University of Virginia, Charlottesville, VA.ORCID 0000-0002-7655-6342

Funding

Modulating aqueous humor outflow with engineered nanoparticles for glaucomaR01EY035088 · NEI · MISSOURI UNIVERSITY OF SCIENCE & TECHNOLOGY · PI Xiaorong Liu, Hu Yang · 2023 to 2026
$2.0M
NEI NIH HHS R01 EY035088
6 · The paper itself

Abstract

Retinal ganglion cell (RGC) degeneration in optic neuropathies is often preceded by neuroinflammatory changes, yet the earliest

Identifiers

PMID41497584
PMCPMC12767297

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.