Evidence map›Paper›PMID 41497579›Full record

ArticlebioRxiv : the preprint server for biology2025

Cellular- and systems-level profiling of amyloid-beta effects on circadian timing.

Kari R Hoyt, Tyler Kyhl, Nicklaus R Halloy, Karl Obrietan

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Kari R HoytDivision of Pharmaceutics and Pharmacology, Ohio State University, Columbus, OH, USA.ORCID 0000-0001-6730-9887
Tyler KyhlDivision of Pharmaceutics and Pharmacology, Ohio State University, Columbus, OH, USA.
Nicklaus R HalloyDivision of Pharmaceutics and Pharmacology, Ohio State University, Columbus, OH, USA.ORCID 0009-0008-2182-1218
Karl ObrietanDepartment of Neuroscience, Ohio State University, Columbus, OH, USA.ORCID 0000-0002-7525-7121

Funding

Alzheimer's disease pathogenesis and the desynchronization of cortico-limbic circadian rhythmsR01AG065830 · NIA · OHIO STATE UNIVERSITY · PI HOYT, KARI RENE, OBRIETAN, KARL H · 2020 to 2024
$3.5M
MAPK signaling: gates, oscillators and circadian timingR01GM133032 · NIGMS · OHIO STATE UNIVERSITY · PI HOYT, KARI RENE, OBRIETAN, KARL H · 2020 to 2023
$1.9M
NIA NIH HHS R01 AG065830NIGMS NIH HHS R01 GM133032
6 · The paper itself

Abstract

Disruption of the circadian timing system has been reported in the preclinical phase of Alzheimer's disease (AD) and is a well-characterized component of mid- and late-stage AD. Given the distributed nature of the circadian timing system, with a central pacemaker in the suprachiasmatic nucleus (SCN) and peripheral clocks throughout the brain, understanding how AD affects this system has been challenging. To investigate how AD may disrupt circadian physiology, we focused on the amyloid-beta peptide, a key contributor to familial early-onset AD. Using the 5xFAD mouse model and

Identifiers

PMID41497579
PMCPMC12767652

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.