Evidence map›Paper›PMID 41497494›Full record

ArticleContinence (Amsterdam, Netherlands)2025

Sensation kinetics identifies novel bladder sensation-capacity curve shapes during urodynamics in patients with urinary urgency.

John E Speich, Annapoorani Narayanan, Mrudula Bandaru, Nyasia Jones, Devina Thapa, Rui Li, Zachary E Cullingsworth, Anna S Nagle, Andrew F Colhoun, Adam P Klausner

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Continence (Amsterdam, Netherlands), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

John E SpeichDepartment of Mechanical & Nuclear Engineering, Virginia Commonwealth University College of Engineering, Richmond, VA, USA.ORCID 0000-0002-8824-4098
Annapoorani NarayananDepartment of Surgery/Division of Urology, Virginia Commonwealth University School of Medicine, Richmond, VA, USA.
Mrudula BandaruDepartment of Surgery/Division of Urology, Virginia Commonwealth University School of Medicine, Richmond, VA, USA.
Nyasia JonesDepartment of Surgery/Division of Urology, Virginia Commonwealth University School of Medicine, Richmond, VA, USA.ORCID 0000-0002-0764-7304
Devina ThapaDepartment of Surgery/Division of Urology, Virginia Commonwealth University School of Medicine, Richmond, VA, USA.
Rui LiDepartment of Mechanical & Nuclear Engineering, Virginia Commonwealth University College of Engineering, Richmond, VA, USA.
Zachary E CullingsworthDepartment of Mechanical & Nuclear Engineering, Virginia Commonwealth University College of Engineering, Richmond, VA, USA.ORCID 0000-0002-4087-9764
Anna S NagleDepartment of Mechanical & Nuclear Engineering, Virginia Commonwealth University College of Engineering, Richmond, VA, USA.
Andrew F ColhounVirginia Urology, Richmond, VA, USA.
Adam P KlausnerDepartment of Surgery/Division of Urology, Virginia Commonwealth University School of Medicine, Richmond, VA, USA.ORCID 0000-0003-3849-7131

Funding

The Detrusor Tension Sensor: A Model for Novel Cystometrics in Overactive BladderR01DK101719 · NIDDK · VIRGINIA COMMONWEALTH UNIVERSITY · PI KLAUSNER, ADAM PHILIP, SPEICH, JOHN E · 2015 to 2023
$2.4M
NIDDK NIH HHS R01 DK101719
6 · The paper itself

Abstract

Objective: Overactive bladder ( Methods: Individuals with moderate-to-severe urgency presenting for clinically indicated UDS were prospectively enrolled after urgency characterization using the International Consultation on Incontinence OAB questionnaire ( Findings: The study included 69 participants (52F, 17M). The distribution of sensation-capacity curve shapes was 7 (10 %) r-shape, 43 (62 %) l-shape, and 19 (28 %) j-shape. A j-shaped curve was significantly associated with severe urgency and with high urgency bother, but not with bladder capacity or DO. Conclusions: The key finding was the association between a j-shaped sensation-capacity curve, demonstrating a rapid acceleration of sensation near the end of filling, with both urgency symptom severity and bother. Curve shapes were not associated with bladder capacity or DO, suggesting that a j-shaped curve may potentially identify a separate driver of urinary urgency. Additional studies are needed to determine whether sensation-capacity curves can be used to identify novel OAB/urgency phenotypes or guide therapy.

Indexed as

Lower urinary tract symptomsOveractive bladderSensationUrinary bladderUrodynamics

Identifiers

PMID41497494
PMCPMC12768493

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.