From overlooked to just right: putting the focus on metronidazole infusion timing for colorectal surgical prophylaxis.

Peter Oakes, Lindsay E Donohue, Sunny Chiao, Susan Ketcham, Traci Hedrick, Rachele Olivier, Amy J Mathers

Abstract read

In one paragraph

Article in Antimicrobial stewardship & healthcare epidemiology : ASHE, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Peter OakesDivision of Infectious Diseases & International Health, Department of Medicine, University of Virginia Health, Charlottesville, VA, USA.ORCID https://orcid.org/0009-0001-4926-0415

Lindsay E DonohueDepartment of Pharmacy, University of Virginia Health System, Charlottesville, VA, USA.

Sunny ChiaoDepartment of Anesthesiology, University of Virginia Health System, Charlottesville, VA, USA.ORCID https://orcid.org/0000-0003-3012-7953

Susan KetchamPerioperative Services, University of Virginia Health System, Charlottesville, VA, USA.

Traci HedrickColon and Rectal Surgery, Division of General Surgery, University of Virginia Health System, Charlottesville, VA, USA.

Rachele OlivierDepartment of Quality and Performance Improvement, University of Virginia Health System, Charlottesville, VA, USA.

Amy J MathersDivision of Infectious Diseases & International Health, Department of Medicine, University of Virginia Health, Charlottesville, VA, USA.ORCID https://orcid.org/0000-0002-3533-6351

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Preoperative prophylaxis efficacy depends on antibiotic infusion completion before incision. In our colorectal program, metronidazole often wasn't completed on time, in contrast to cefazolin. A multidisciplinary effort standardized its administration timing, improving infusion completion rates. We evaluated the impact of this intervention on surgical site infections in colorectal surgery.

Identifiers

PMID41497432

DOI10.1017/ash.2025.10260

PMCPMC12766523

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.