ArticleiScience2025
Genetic evidence supports primary biliary cholangitis as a risk factor for lacunar stroke.
Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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5 authors.
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Abstract
Primary biliary cholangitis (PBC) is a chronic autoimmune liver disease, while lacunar stroke is a common cerebrovascular subtype. Understanding potential systemic vascular consequences of PBC is crucial for patient management. Using a two-sample Mendelian randomization (MR) approach, we investigated the causal effect of PBC on lacunar stroke risk. We utilized genetic instruments for PBC from large-scale genome-wide association studies and tested their association with lacunar stroke in independent datasets. In the discovery analysis, genetically predicted PBC was associated with an increased risk of lacunar stroke (odds ratio [OR] = 1.0635, 95% confidence interval [CI]: 1.0224-1.1063;
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