Evidence map›Paper›PMID 41497390›Full record

ArticleAdvanced functional materials2025

Cold Quad-Modal Nanocomplex for Precise and Quantitative In Vivo Stem Cell Tracking.

Ali Shakeri-Zadeh, Chao Wang, Shreyas Kuddannaya, Saleem Yousf, Jeff W M Bulte

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced functional materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ali Shakeri-ZadehThe Russell H. Morgan Department of Radiology and Radiological Science, Division of MR Research, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Chao WangThe Russell H. Morgan Department of Radiology and Radiological Science, Division of MR Research, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Shreyas KuddannayaThe Russell H. Morgan Department of Radiology and Radiological Science, Division of MR Research, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Saleem YousfThe Russell H Morgan Department of Radiology and Radiological Science, Division of Cancer Imaging Research, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Jeff W M BulteThe Russell H. Morgan Department of Radiology and Radiological Science, Division of MR Research, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Funding

WORK ORDER 126643 B539 EXPAND IC SUITE75N91019D00024 · NIAID · LEIDOS BIOMEDICAL RESEARCH, INC. · PI BRISCOE, LYNN · 2019 to 2025
$3932.6M
Training/Dissemination-Resource for Molecular Imaging Agents in Precision MedicineP41EB024495 · NIBIB · UT SOUTHWESTERN MEDICAL CENTER · PI MARTIN G POMPER · 2017 to 2026
$11.8M
Precision magnetic hyperthermia by integrating magnetic particle imagingR01CA257557 · NCI · JOHNS HOPKINS UNIVERSITY · PI BULTE, JEFF W., IVKOV, ROBERT · 2021 to 2025
$3.2M
Upgrade of the 11.7T Research Scanner at the F.M. Kirby Research CenterS10OD032188 · OD · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI VAN ZIJL, PETER CM · 2024 to 2024
$1.7M
Quantitative Dynamic Monitoring of MSCs and MSC-EVs in a Mouse Model of Intracerebral HemorrhageR01EB036468 · NIBIB · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Shreyas Kuddannaya · 2025 to 2026
$1.3M
Non-Invasive Tracking of Genome-Corrected iPS cells in ALSUH3EB028904 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI BULTE, JEFF W. · 2021 to 2022
$950k
Magnetic Particle Imaging ScannerS10OD026740 · OD · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI BULTE, JEFF W. · 2019 to 2019
$600k
Non-Invasive Tracking of Genome-Corrected iPS cells in ALSUH2EB028904 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI BULTE, JEFF W. · 2019 to 2020
$482k
NCI NIH HHS 75N91019D00024NCI NIH HHS R01 CA257557NIBIB NIH HHS P41 EB024495NIBIB NIH HHS R01 EB036468NIBIB NIH HHS UH2 EB028904NIBIB NIH HHS UH3 EB028904NIH HHS S10 OD026740NIH HHS S10 OD032188
6 · The paper itself

Abstract

Current single imaging modalities typically lack the ability to simultaneously offer detailed anatomical visualization and quantitative cellular information, which is crucial for evaluating and improving therapeutic efficacy. This work develops a cold (non-radioactive) quad-modal imaging nanocomplex for magnetic resonance imaging (MRI), magnetic particle imaging (MPI), computed tomography (CT), and multispectral optoacoustic tomography (MSOT) within a single nanoplatform, that is, Albumin-Bismuth-Superparamagnetic iron oxide or ABS. The chemically engineered complex is composed of bovine serum albumin as biocompatible matrix, superparamagnetic iron oxide as MRI and MPI agents, and optoradiopaque bismuth sulfide as CT and MSOT agents. This work demonstrates here its first use for high-resolution, real-time, and quantitative in vivo imaging of mesenchymal stem cells transplanted in mouse brain. This versatile nanocomplex may find applications for non-invasive monitoring cell transfer and cell transplantation in vivo using multiple imaging approaches.

Indexed as

cold nanocomplexmultimodal imagingnon-invasive imagingquantitative cell trackingstem cell labeling

Identifiers

PMID41497390
PMCPMC12768337

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.