ArticleObstetrics and gynecology international2025
Associations of Biotin Levels in Serum and Follicular Fluid With ICSI Success: A Cross-Sectional Study From Iraq.
Article in Obstetrics and gynecology international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Associations of Biotin Levels in Serum and Follicular Fluid With ICSI Success: A Cross-Sectional Study From Iraq.Obstetrics and gynecology international · 2025Article
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3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Background: Biotin (vitamin B7) has been identified as an essential cofactor within metabolism and gene expression. The purpose of this study is to evaluate the level of biotin within serum and follicular fluid aspirates among infertile women undergoing IVF cycles and to compare these levels with ovulation sensitivity and rates of pregnancy. Methods: In this observational study with 50 patients with infertility receiving intracytoplasmic sperm injection (ICSI) treatment, women were classified according to ovarian responsiveness to anti-Mullerian hormone (AMH) levels and the number of retrieved eggs. At the time of egg retrieval, the levels of biotin in the blood and the ovarian fluid were tested. The study maintained strict reporting according to the STROBE criteria. Results: There was no significant difference with respect to either serum levels or follicular fluids' biotin among normal responders, poor responders, and hyperresponders. In contrast, there was an inverse correlation between the values of follicular biotin and AMH ( Conclusion: Concentrations in serum and follicular fluid of biotin do not play any role in IVF outcome. The negative correlation with AMH and BMI levels might indicate the role of biotin in the ovaries as an indicator of ovarian metabolism. The result provides valuable data in understanding the possible role of biotin in the microenvironment of the ovaries and the need to study it further.
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