Evidence map›Paper›PMID 41497354›Full record

ArticleObstetrics and gynecology international2025

When to Choose In Vitro Fertilization (IVF) When Postponing Conceiving: The Age-Related Risk of IVF Failure at an Advanced Age.

Zhiyan Chen, Duoduo Zhang, Zhengyi Sun, Qi Yu, Chenyang Zhao, ChangZhong Li

Abstract read
In one paragraph

Article in Obstetrics and gynecology international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Zhiyan ChenDepartment of Obstetrics & Gynecology, Peking University Shenzhen Hospital, Shenzhen, China, pkuszh.com.ORCID https://orcid.org/0000-0002-1695-1455
Duoduo ZhangDepartment of Obstetrics & Gynecology, Chinese Academy of Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, China, cacms.ac.cn.ORCID https://orcid.org/0000-0002-2519-8354
Zhengyi SunDepartment of Obstetrics & Gynecology, Chinese Academy of Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, China, cacms.ac.cn.ORCID https://orcid.org/0000-0001-6363-9723
Qi YuDepartment of Obstetrics & Gynecology, Chinese Academy of Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, China, cacms.ac.cn.ORCID https://orcid.org/0000-0001-9737-5957
Chenyang ZhaoMedical Technology Department, The Islands Healthcare Complex - Macao Medical Center of Peking Union Medical College Hospital, Macao, China.ORCID https://orcid.org/0000-0001-9389-0652
ChangZhong LiDepartment of Obstetrics & Gynecology, Peking University Shenzhen Hospital, Shenzhen, China, pkuszh.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: To validate previous age subgrouping methods and provide an optimal age reference for women planning to delay in vitro fertilization (IVF). Methods: From July 2014 to March 2018, 3012 patients that received IVF/intracytoplasmic sperm injection (ICSI) were continuously recruited in this retrospective, single-center study. We analyzed the relationships of baseline characteristics and IVF outcomes. A smooth fitting curve depicting the association of age and live birth was plotted using the generalized additive model (GAM) method. We also evaluated the association of age and live birth among different age groups (> 20, ≤ 35; > 35, ≤ 37; > 37, ≤ 40; and > 40). Results: Age, duration of infertility, and baseline follicle-stimulating hormone (FSH) were significantly related to the live birth rate. The adjusted Odd Ratio (OR) value of age was 0.95 ( Conclusion: The age of 35 can be referred to as the safe time point when the IVF success rate does not decline with age. And the risk of IVF failure increases rapidly in the period of 35-37 and 37-40.

Indexed as

agefertilityin vitro fertilization (IVF)

Identifiers

PMID41497354
PMCPMC12767371

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.