ArticleERJ open research2026
Key spirometric determinants of future airflow obstruction in children with asthma.
Article in ERJ open research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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3 authors.
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Abstract
Background: There is increasing concern about children with asthma developing progressive lung function impairment. The objective of the present study was to identify the best spirometric determinants of subsequent development of airflow obstruction (AO) in children with asthma in the clinic setting. Methods: We assembled two retrospective cohort studies of children aged 6-17 years, managed in tertiary-care asthma clinics, with medical and drug coverage, and repeated spirometry testing. The primary outcome was AO, defined as pre-bronchodilation (pre-BD) forced expiratory volume in 1 s (FEV Results: Of 509 eligible children (mean age: 10 years), 17% subsequently developed AO. In patients with ≥1 prior visit, the likelihood of future AO independently increased by almost 4-fold (adjusted OR 3.91 (95% CI 2.54-6.01)) for every 1 z-score lower FEV Interpretation: Two spirometric parameters independently increased the likelihood of subsequently developing AO, namely FEV
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