Evidence map›Paper›PMID 41497323›Full record

ArticleEndocrine and metabolic science2025

Mineralocorticoid receptor antagonists reduce inflammatory signaling independent of myofiber mineralocorticoid receptor.

Jeovanna Lowe, Arden B Piepho, Chetan K Gomatam, Peyton Debell, Megan N Ballinger, Jill A Rafael-Fortney

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Endocrine and metabolic science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jeovanna LoweDepartment of Physiology & Cell Biology, College of Medicine, The Ohio State University, Columbus, OH, USA.
Arden B PiephoDepartment of Physiology & Cell Biology, College of Medicine, The Ohio State University, Columbus, OH, USA.
Chetan K GomatamDepartment of Physiology & Cell Biology, College of Medicine, The Ohio State University, Columbus, OH, USA.
Peyton DebellDepartment of Physiology & Cell Biology, College of Medicine, The Ohio State University, Columbus, OH, USA.
Megan N BallingerDivision of Pulmonary, Critical Care and Sleep Medicine, Dept. of Internal Medicine, Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University, Columbus, OH, USA.
Jill A Rafael-FortneyDepartment of Physiology & Cell Biology, College of Medicine, The Ohio State University, Columbus, OH, USA.

Funding

Training To Provide the Knowledge, Skills, and Culture To the Next Generation of Cardiovascular ScientistsT32HL134616 · NHLBI · OHIO STATE UNIVERSITY · PI Brandon J Biesiadecki, Jill A Rafael-Fortney · 2017 to 2026
$2.6M
Mechanisms of mineralocorticoid receptor antagonism on inflammation in muscular dystrophyR01NS124681 · NINDS · OHIO STATE UNIVERSITY · PI Jill A Rafael-Fortney · 2022 to 2026
$2.1M
NHLBI NIH HHS T32 HL134616NINDS NIH HHS R01 NS124681
6 · The paper itself

Abstract

Chronic inflammation is a feature of Duchenne muscular dystrophy (DMD), a degenerative striated muscle disease. Mineralocorticoid receptor (MR) antagonists (MRAs) have demonstrated clinical benefit on later onset DMD cardiomyopathy, and preclinical studies in mouse models have demonstrated efficacy on multiple steps of skeletal muscle pathology. MRA treatment of the

Indexed as

InflammationmdxMineralocorticoid receptorMuscular dystrophyMyeloid

Identifiers

PMID41497323
PMCPMC12768496

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.