ArticleIndian journal of endocrinology and metabolism
Prevalence and Clinical Associations of Adrenal Dysfunction in People Living with Human Immunodeficiency Virus: A Prospective Cohort Study.
Article in Indian journal of endocrinology and metabolism. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Association of antiretroviral therapy regimens with serum cortisol abnormalities in people living with HIV/AIDS: a retrospective study.Frontiers in endocrinology · 2026Article
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9 authors.
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Abstract
Introduction: Adrenal insufficiency (AI) is more prevalent in people living with human immunodeficiency virus (HIV) (PLHIV) than in the general population, yet screening is infrequent. Untreated disease may have grave consequences, including death. This study assessed AI's prevalence and predictive factors in both stable and advanced PLHIV Indian populations and their short-term outcomes. Methods: Participants were classified based on World Health Organization (WHO) clinical stage and cluster of differentiation (CD) 4 count. Group 1 included those with advanced disease (CD4 < 200 or stage 3/4), while Group 2 had stable disease (CD4 > 200, stage 1/2). An Acton Prolongatum Results: In Group 1, AI was observed in 30.56% and 19.44% of participants at stimulated 120-min cortisol levels below 19.5 μg/dL and 18 μg/dL, respectively, while in Group 2, it was seen in 71.43% and 48.57%, respectively. In univariate analysis for predicting AI, hyponatraemia emerged as a significant variable (odds ratio (OR): 10.8, 95% confidence interval (CI): 1.2-97.7, Conclusion: AI is prevalent in PLHIV, emphasizing the need for screening. Hyponatraemia may aid targeted screening. Low DHEA-S, elevated basal cortisol and high cortisol/DHEA-S ratios are markers of advanced HIV and increased mortality.
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