ArticleIndian journal of endocrinology and metabolism
The Utility of HbA1c and Fructosamine in Evaluating the Glucose Tolerance in Adult Patients with Transfusion-Dependent Beta-Thalassemia.
Article in Indian journal of endocrinology and metabolism. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Dynamic OGTT-Derived Indices Outperform Fasting HOMA-2 for Detecting Dysglycemia in Transfusion-Dependent β-Thalassemia.Mediterranean journal of hematology and infectious diseases · 2026Article
- Glycemic assessment when hemoglobin A1c is unreliable: a clinical-laboratory framework for kidney disease, anemia, and hemoglobinopathies.Frontiers in endocrinology · 2026Review
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5 authors.
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Abstract
Introduction: Transfusion-dependent beta-thalassemia (TDT) leads to iron overload, contributing to glucose intolerance through insulin resistance and pancreatic beta-cell dysfunction. The reliability of HbA1c in diagnosing diabetes mellitus in TDT is questionable due to altered red blood cell dynamics. Fructosamine, reflecting short-term glycaemia, offers a potential alternative. This study assesses the utility of HbA1c and fructosamine in evaluating glucose tolerance in adult TDT patients. Methods: In this cross-sectional study, 61 adult TDT patients were recruited from a tertiary care centre in North India. Glucose tolerance was assessed using fasting plasma glucose (FPG) and a 2-hour oral glucose tolerance test (2Hr-OGTT) as gold standards. HbA1c and serum fructosamine levels were measured. Sensitivity, specificity, and diagnostic accuracy of these two tests and their correlation with FPG and 2Hr-OGTT were analysed. Results: Among the 61 patients of TDT (median age: 27 years), 63.9% had normal glucose tolerance (NGT), while 36.1% exhibited glucose intolerance (24.6% prediabetes, 11.5% diabetes). HbA1c and fructosamine were significantly elevated in glucose-intolerant patients compared to those with NGT. HbA1c significantly correlated with FPG (rho = 0.42, Conclusion: While both markers were elevated in glucose-intolerant TDT patients, their diagnostic reliability remains limited. FPG and 2Hr-OGTT remain the gold standard for diagnosing glucose intolerance in TDT.
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