Evidence map›Paper›PMID 41497251›Full record

ArticleJournal of stem cells & regenerative medicine2025

INVESTIGATING THE EFFECT OF MESENCHYMAL STEM CELLS ON THE PROLIFERATION PHASE OF DUODENAL WOUND HEALING.

Eko Setiawan, Dimas Irfan Nabih

Abstract read
In one paragraph

Article in Journal of stem cells & regenerative medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Eko SetiawanDepartment of Surgery, Faculty of Medicine, Universitas Islam Sultan Agung, Semarang, Indonesia.
Dimas Irfan NabihDepartment of Postgraduate Biomedical Science, Faculty of Medicine, Universitas Islam Sultan Agung, Semarang, Indonesia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Duodenal perforation represents a critical gastrointestinal surgical emergency, often associated with high rates of morbidity and mortality. Mesenchymal stem cells (MSCs) have the potential to enhance wound healing by releasing various growth factors and antiinflammatory cytokines. This study aims to evaluate and analyze the impact of MSCs on the healing process of duodenal perforation wounds. Method: MSCs were extracted from the umbilical cords of rats and injected into the site of duodenal perforation at two different doses: 1.5 × 10 Results: Significant increases in the expression of TGF-β, fibroblasts, collagen, and α-SMA were observed in the treatment groups compared to the control group on both day 3 and day 7. Conclusion: The administration of MSCs significantly enhances the proliferation phase of duodenal wound healing through the increased expression of fibroblasts, collagen, TGF-β, and α-SMA.

Indexed as

CollagenDuodenal perforationFibroblastMesenchymal stem cellsTGF-βα-SMA

Identifiers

PMID41497251
PMCPMC12766067

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.