Higher admission IL-6 levels are associated with higher platelet levels at discharge in sepsis patients.

Mubing Qin, Xin Lu, Joseph Harold Walline, Zengrui Song, Huadong Zhu, Yanxia Gao, Yi Li

Abstract read

In one paragraph

Article in Annals of medicine and surgery (2012), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mubing QinEmergency Department, The State Key Laboratory for Complex, Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.

Xin LuEmergency Department, The State Key Laboratory for Complex, Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.

Joseph Harold WallineDepartment of Emergency Medicine, Penn State Health, Milton S. Hershey Medical Center and Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA.ORCID https://orcid.org/0000-0001-9582-1044

Zengrui SongEmergency Department, The State Key Laboratory for Complex, Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.

Huadong ZhuEmergency Department, The State Key Laboratory for Complex, Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.

Yanxia GaoEmergency Department, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Yi LiEmergency Department, The State Key Laboratory for Complex, Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Sepsis is a life-threatening organ dysfunction syndrome, with an overall mortality rate of 32.8%. Platelets have been shown to have a central role in the pathogenesis of a diverse array of immune-mediated and infectious diseases, and both thrombocytopenia and platelet hyperreactivity independently correlate with elevated sepsis-related morbidity and mortality. Methods: From February 2021 to June 2022, patients diagnosed with sepsis (according to the Sepsis 3.0 criteria) from the emergency department were screened and enrolled in a prospective observational cytokine analysis cohort. "Bio-Plex Pro Human Cytokine Grp I Panel 17-plex" was used for cytokines analysis. Patients were stratified into high- and low-platelet groups using a discharge platelet threshold of 150 × 10 Results: Fifty-seven patients were enrolled and were classified into high- and low-platelet groups (31 vs 26). IL-6 had a significant difference between the two groups after adjusting for admission platelet level and length of stay in hospital (2072 vs 107.1, Conclusion: Higher IL-6 levels at admission for sepsis were associated with higher platelet levels at discharge.

Indexed as

IL-6plateletsepsis

Identifiers

PMID41497125

DOI10.1097/MS9.0000000000004485

PMCPMC12768105

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