ArticleAnnals of medicine and surgery (2012)2026
Prevalence of depression among oocyte donor candidates: a systematic review and meta-analysis.
Article in Annals of medicine and surgery (2012), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Infertility, affecting approximately 17.5% of individuals worldwide, is increasing globally, making oocyte donation an important reproductive option. However, it is associated with physical and psychological risks, as well as social stigma. The primary aim of this systematic review and meta-analysis is to estimate the prevalence of depression among women undergoing oocyte donation, and the secondary aim is to assess changes in depressive symptoms before and after the donation process. Methods: A systematic and thorough literature search was performed from 1 January 1990 to 31 December 2024 using PubMed, Web of Science, Scopus, and Embase databases. Reference lists of relevant articles, as well as Google Scholar, were manually reviewed to identify additional eligible studies. The risk of bias of included studies was independently assessed using the Hoy checklist for prevalence studies. Meta-analyses were conducted utilizing STATA version 18.0, applying a random-effects model to account for potential heterogeneity among studies. Results: The meta-analysis of five studies estimated a pooled depression prevalence of 2% [95% confidence interval (CI): 0-6%; Conclusions: Depression affects a small but notable proportion of women undergoing oocyte donation, with no significant changes in depressive symptoms before and after the procedure.
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