ArticleAnnals of medicine and surgery (2012)2026
Comparing the efficacy of pethidine and ketorolac in managing postoperative pain following orthopedic fracture surgery in addicts: a prospective clinical study.
Article in Annals of medicine and surgery (2012), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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5 authors.
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Abstract
Objective: Effective postoperative pain management in patients with substance use disorder undergoing orthopedic surgery remains challenging. This study aimed to compare the analgesic efficacy and safety of pethidine and ketorolac in this specific population. Methods: In this prospective comparative study, 62 patients with substance use disorder undergoing orthopedic fracture repair were randomized into two groups. The ketorolac group ( Results: Demographic characteristics, fracture patterns, and substance use profiles were comparable between groups. Both groups showed a significant pain reduction from baseline to 24 hours postoperatively. The mean reduction in VAS scores was 4.0 ± 1.15 in the ketorolac group and 4.25 ± 0.99 in the pethidine group (P = 0.35). No significant differences in analgesic efficacy were observed at any time point. Both medications were well tolerated with no reported adverse effects. Conclusion: Both pethidine and ketorolac provided effective postoperative analgesia in patients with substance use disorder undergoing orthopedic fracture surgery, with comparable efficacy and safety profiles. The choice between these analgesics should consider individual patient characteristics and the potential for substance misuse.
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