ArticleAnnals of medicine and surgery (2012)2026
The association of inflammatory response with speckled global strain in recovered patients with myocarditis.
Article in Annals of medicine and surgery (2012), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Objectives: This study aimed to investigate the relationship between simple, routinely available inflammatory markers and residual impairment of left ventricular (LV) function assessed by 2D global longitudinal strain (GLS) in patients recovered from myocarditis. Materials and Methods: This prospective study included patients diagnosed with Myocarditis who were followed in our heart failure clinic. All participants underwent conventional echocardiography and 2D strain analysis at follow-up. Echocardiographic data was compared with age and sex-matched healthy controls. The study group's bloodwork was analyzed for inflammatory biomarkers, including neutrophil-to-lymphocyte ratio (NLR), at defined time intervals starting from admission. Results: A total of 104 myocarditis patients [22 women, mean age 30.9 ± 8.5 years, baseline LV ejection fraction (LVEF) 56.8 ± 6.8%] were included. At a median follow-up of 78.4 months (IQR: 53.5-99.2), median GLS remained significantly less negative compared with healthy controls [-18.0% (IQR: -18.8 to -17.5) vs -21.4% (IQR: -22.7 to -19.4); Conclusion: Elevated inflammatory markers at presentation, particularly NLR, were associated with impaired GLS at follow-up, independent of baseline demographic and clinical covariates. The predictive value of NLR appeared more evident in males, though limited female representation precludes firm sex-specific conclusions. NLR may serve as a simple, cost-effective marker for identifying patients at risk of residual subclinical LV dysfunction after myocarditis, but larger, sex-balanced cohorts are required to confirm these findings.
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