ArticleAnnals of medicine and surgery (2012)2026
Surfactant protein D expression and clinical value of hypobaric hypoxia-induced acute lung injury and acute respiratory distress syndrome patients.
Article in Annals of medicine and surgery (2012), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Exploratory Changes in Surfactant Protein D During Intermittent Hypoxia and Modulation by Galectin-3 Inhibition.Advances in respiratory medicine · 2026Article
- Chronic hypoxia adaptation at high altitude: a perspective on Its potential role in mortality in viral pneumonia-associated ARDS and implications for personalized critical care.Critical care (London, England) · 2026Review
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6 authors.
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Abstract
Background: Surfactant protein D (SP-D) has been widely studied in infectious diseases, yet its role in aseptic inflammation remains poorly understood. This study aims to evaluate the clinical and mechanistic relevance of SP-D in acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) induced by hypobaric hypoxia. Methods: A hypobaric hypoxia-induced ALI model was established in rats at different time intervals (24, 48, and 72 h). SP-D levels were measured in lung tissue, bronchoalveolar lavage fluid (BALF), and serum, alongside inflammatory markers and hypoxia-inducible factor-1α (Hif-1α) expression. Serum SP-D levels were also compared between ARDS patients and healthy controls. Results: Hypobaric hypoxia-induced dose-dependent lung injury in rats, with elevated inflammatory cytokines, increased Hif-1α expression, reduced SP-D in lung tissue, and increased SP-D in BALF and serum. BALF SP-D positively correlated with lung injury severity, while lung SP-D levels showed a negative correlation. In ARDS patients, serum SP-D levels were significantly elevated and negatively correlated with the oxygenation index. Conclusion: SP-D exhibits dynamic expression changes in response to hypoxia-induced lung injury and holds potential as a biomarker for assessing lung injury severity and predicting outcomes in ARDS.
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