ArticleRSC advances2026
Baicalin protects against heat-induced multiorgan dysfunction
Article in RSC advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- Baicalin as a multifunctional flavone glycoside: pharmacological mechanisms, ADME profile, and therapeutic potential.Naunyn-Schmiedeberg's archives of pharmacology · 2026Review
- Heat shock proteins in male infertility: recent advances and clinical implications.Frontiers in cell and developmental biology · 2026Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Heatstroke-induced multiorgan dysfunction represents a life-threatening clinical emergency characterized by systemic oxidative stress, inflammation, and metabolic collapse across vital organs. Despite advances in supportive care, there remains a critical lack of multitarget pharmacological interventions that address the underlying molecular pathology. Here, we evaluated baicalin, a naturally occurring flavone glycoside, for its multiorgan protective efficacy against systemic hyperthermia through an integrated computational-experimental framework. Five key heat-responsive proteins-heat shock protein 70 (Hsp70), heat shock protein 27 (Hsp27), aquaporin-1 (AQP1), interleukin-6 receptor (IL-6R), and cytochrome P450 3A4 (CYP3A4)-were identified as therapeutic targets based on their roles in heat-induced stress and organ injury. Molecular docking revealed strong binding affinities (Δ
Identifiers
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Registered trials
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