ArticleSports medicine and health science2025
Plasma cardiovascular stress biomarkers response to marathon running.
Article in Sports medicine and health science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Trimethylamine N-oxide in exercise physiology: a gut microbiota-derived signal linking metabolic stress, redox balance and cardiometabolic health.European journal of applied physiology · 2026Review
- Long-Distance Trail Running Induces Inflammatory-Associated Protein, Lipid, and Purine Oxidation in Red Blood Cells.Blood red cells & iron · 2026Article
- Exploring Salivary Thiocyanate as a Novel Biomarker of Physical Activity Response.Molecules (Basel, Switzerland) · 2025Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Habitual physical activity is known to support cardiovascular health. However, when intensive exercise is performed for long durations, it can negatively affect the cardiovascular system. We evaluated the exercise-induced physiological responses of cardiac markers in male marathon runners based on basal plasma trimethylamine-N-oxide (TMAO) levels, a metabolite related to major adverse cardiovascular events. Methods: Blood samples from 28 marathon runners were collected two weeks before the marathon run (baseline), after finishing the race (post-marathon), and two weeks after the race (2 weeks post-marathon). Serum cardiac troponin I (cTnI), endothelin-1 (ET-1), galectin-3, pentraxin-3, human growth differentiation factor 15, and neopterin were determined by the enzyme immunoassay method. Plasma trimethylamine (TMA) and TMAO were measured by the ultra-high-performance liquid chromatography-mass spectrometry method. Results: Running a marathon increased levels of circulating biomarkers. A greater post-marathon elevation of cTnI and ET-1 was associated with baseline plasma TMAO levels ( Conclusion: Greater post-marathon elevation of cTnI and ET-1 was associated with higher baseline plasma TMAO levels. Therefore, TMAO could potentially serve as a new marker in assessing the response of cardiovascular stress biomarkers to marathon running.
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Registered trials
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