ReviewJournal of pain research2025
Efficacy and Safety of Pulsed Radiofrequency Combined with Platelet-Rich Plasma in the Treatment of Postherpetic Neuralgia: A Systematic Review and Meta-Analysis.
Review in Journal of pain research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Platelet-Rich Plasma for Postherpetic Neuralgia: Proposed Mechanisms, Clinical Evidence, and Future Research Directions.Journal of pain research · 2026Review
- Efficacy of Pulsed Radiofrequency Combination Therapy for Postherpetic Neuralgia: A Systematic Review and Bayesian Network Meta-Analysis.Journal of pain research · 2026Review
- Platelet-rich therapies in cutaneous and mucocutaneous disorders characterized by inflammatory tissue responses: mechanistic insights and clinical evidence.Frontiers in medicine · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Herpes zoster-associated neuralgia (HZN) is a disease caused by the reactivation of the varicella-zoster virus (VZV) that is latent within the spinal nerves, with a major impact on patients' quality of life. The objective of this study is to evaluate the efficacy and safety of Pulsed Radiofrequency (PRF) combined with Platelet-Rich Plasma (PRP) in the treatment of HZN, comparing it with PRF alone. Methods: A thorough search was conducted on multiple databases. Several clinical studies from the inception of each database up to December 2024 were included in the study. The primary clinical outcome was the postoperative pain intensity score. Secondary clinical outcomes encompassed sleep quality, the utilization of rescue analgesics postoperatively, and the incidence of adverse events. Results: The final analysis incorporated a total of seven studies, encompassing 568 subjects. With regard to the alleviation of pain, PRF combined with PRP therapy has shown more significant pain relief for HZN when compared with conventional PRF therapy. The combination of PRF and PRP therapy has been demonstrated to be more efficacious in enhancing patients' sleep quality. With regard to the administration of postoperative rescue analgesics, the dosage of such medication was found to be lower in cases where PRF was combined with PRP therapy. The incidence of adverse events was consistent across both groups. Conclusion: The PRF - PRP is more effective than the traditional radiofrequency pulse therapy in treating HZN. This combination has been demonstrated to enhance sleep quality and reduce the necessity for postoperative rescue analgesics. The potential for this approach extends to its utilization as a novel therapeutic modality for HZN.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.