Evidence map›Paper›PMID 41496792›Full record

ArticleJBMR plus2026

Estrogen signaling in PDGFRα+ cells positively regulates cortical bone metabolism via IGFBP5 in female mice.

Aoi Ikedo, Reina Aoki, Hiroshi Sakai, Noritaka Saeki, Yuta Yanagihara, Jonathan Moody, Miki Kojima, Tsukasa Kouno, Yoshinari Ando, Kazunori Hino and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JBMR plus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Aoi IkedoDivision of Integrative Pathophysiology, Proteo-Science Center, PIAS, Ehime University, Toon 791-0295, Japan.
Reina AokiDepartment of Hepato-Biliary-Pancreatic Surgery and Breast Surgery, Ehime University Graduate School of Medicine, Toon 791-0295, Japan.
Hiroshi SakaiDivision of Integrative Pathophysiology, Proteo-Science Center, PIAS, Ehime University, Toon 791-0295, Japan.
Noritaka SaekiDivision of Integrative Pathophysiology, Proteo-Science Center, PIAS, Ehime University, Toon 791-0295, Japan.
Yuta YanagiharaDivision of Integrative Pathophysiology, Proteo-Science Center, PIAS, Ehime University, Toon 791-0295, Japan.
Jonathan MoodyLaboratory for Regulatory Genomics, RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan.
Miki KojimaLaboratory for Regulatory Genomics, RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan.
Tsukasa KounoLaboratory for Regulatory Genomics, RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan.
Yoshinari AndoLaboratory for Regulatory Genomics, RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan.
Kazunori HinoDepartment of Orthopaedic Surgery, Ehime University Graduate School of Medicine, Toon 791-0295, Japan.
Tomofumi KinoshitaDepartment of Orthopaedic Surgery, Ehime University Graduate School of Medicine, Toon 791-0295, Japan.
Piero CarninciLaboratory for Regulatory Genomics, RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan.
Jay W ShinLaboratory for Regulatory Genomics, RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan.
Chung-Chau HonLaboratory for Regulatory Genomics, RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan.ORCID https://orcid.org/0000-0002-3741-7577
Akiyoshi UezumiDivison of Cell Heterogeneity, Medical Research Center for High Depth Omics, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812-0054, Japan.
Yoshiaki KameiDepartment of Hepato-Biliary-Pancreatic Surgery and Breast Surgery, Ehime University Graduate School of Medicine, Toon 791-0295, Japan.
Yuuki ImaiDivision of Integrative Pathophysiology, Proteo-Science Center, PIAS, Ehime University, Toon 791-0295, Japan.ORCID https://orcid.org/0000-0002-6119-0034

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The prevalence of both osteoporosis and sarcopenia increases with age and about 60% of elderly sarcopenia patients also develop osteoporosis. However, the co-occurrence of osteoporosis and sarcopenia remains unclear. We performed single-cell 5' RNA-seq on human skeletal muscle tissues and investigated the enrichment of heritability for musculoskeletal traits in cell type specific cis-regulatory regions. We found the fibroblast-specific cis-regulatory regions are highly enriched in the heritability of bone mineral density (BMD). Using genome-wide association study, we identified estrogen receptor α (

Indexed as

bone metabolismestrogenhuman cell atlasIgfbp5PDGFRα+ cells

Identifiers

PMID41496792
PMCPMC12766917

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.