Evidence map›Paper›PMID 41496781›Full record

ArticleJournal of clinical and translational science2025

Moving from a pilot study to large pragmatic trial in primary care settings: A study on acute rhinosinusitis.

Daniel Merenstein, Bruce Barrett, Sebastian T Tong, Aleksandra E Zgierska, David P Rabago, Derjung M Tarn, Keisha Herbin Smith, Gabriela Villalobos, Danielle Schramm, Cameron Casey and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical and translational science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Daniel MerensteinGeorgetown University Medical Center, Department of Family Medicine, Washington, DC, USA.ORCID https://orcid.org/0000-0002-8808-6907
Bruce BarrettUniversity of Wisconsin - Madison, Department of Family Medicine and Community Health, Madison, WI, USA.
Sebastian T TongUniversity of Washington, Department of Family Medicine, Seattle, WA, USA.
Aleksandra E ZgierskaPenn State College of Medicine, Department of Family and Community Medicine, Hershey, PA, USA.ORCID https://orcid.org/0000-0002-7773-6003
David P RabagoPenn State College of Medicine, Department of Family and Community Medicine, Hershey, PA, USA.
Derjung M TarnDavid Geffen School of Medicine at UCLA, Department of Family Medicine, Los Angeles, CA, USA.
Keisha Herbin SmithGeorgetown University Medical Center, Department of Family Medicine, Washington, DC, USA.
Gabriela VillalobosVirginia Commonwealth University, Department of Family Medicine and Population Health, Richmond, VA, USA.
Danielle SchrammDavid Geffen School of Medicine at UCLA, Department of Family Medicine, Los Angeles, CA, USA.
Cameron CaseyDavid Geffen School of Medicine at UCLA, Department of Family Medicine, Los Angeles, CA, USA.
Tina P TanGeorgetown University Medical Center, Department of Family Medicine, Washington, DC, USA.
Charles R FencilVirginia Commonwealth University, Department of Family Medicine and Population Health, Richmond, VA, USA.
Stephen FernandezGeorgetown University Medical Center, Department of Family Medicine, Washington, DC, USA.
Mihriye MeteMedStar Health Research Institute, Columbia, MD, USA.
Nawar SharaMedStar Health Research Institute, Columbia, MD, USA.
Nicholas FrankoUniversity of Washington, Department of Family Medicine, Seattle, WA, USA.ORCID https://orcid.org/0000-0001-8165-6332
Jessy SparenborgGeorgetown University Medical Center, Department of Family Medicine, Washington, DC, USA.
Alex H KristVirginia Commonwealth University, Department of Family Medicine and Population Health, Richmond, VA, USA.ORCID https://orcid.org/0000-0003-4060-9155

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Acute rhinosinusitis is one of the most common conditions seen in primary care. One in seven adults are diagnosed with ARS annually, resulting in one in five of all antibiotic prescriptions. Yet there has been limited research comparing the effectiveness of widely used treatments such as antibiotics and nasal steroids. Conducting such a trial in the context of decades of established practice poses unique challenges. Methods: A feasibility phase was conducted with continuing feedback to provide refinement and guidance regarding the design of a large-scale, pragmatic randomized controlled trial. The pilot trial assessed the ability to enroll, retain, and evaluate adherence to the intervention and assessment protocols. Results: The feasibility phase allowed us to seek input from patients and experts. This resulted in changes pre and post pilot that will impact the full study. Conclusion: Expert panels and a patient advisory committee recommended critical changes to our study design. Stakeholder engagement is a key component of this funding source and was widely used throughout the 18-months. An achieved primary goal of the feasibility phase was to evaluate recruitment and study methods prior to implementing a large clinical trial that requires significant resources.

Indexed as

acute rhinosinusitisantibiotic stewardshipclinical researchPoint of care testprimary care

Identifiers

PMID41496781
PMCPMC12766510

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.